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Re: [IPk] Soluble & PZI mixture

Barry I vaguely remember the consequences of PZI. It was the first ever 
insulin I was put on in 1959. iwas on it for 5 years and teh taken off due 
to severe hypos I can remember my mother recoveing me from them with sticky 
oange juuice and sugar and screaming at her because there wer goblins 
dancing on my feet!!! It must have contained LSD or something!!(she verified 
this with me. I enjoy reading your accounts of Diabetes it certainly brings 
back memoyies. I used to think that I was the omly one in the world to 
suiier the indignities of diabetes we've come a long way since clinitest 
tablets! Carmel

>From: "Barry Squire" <email @ redacted>
>Reply-To: email @ redacted
>To: <email @ redacted>
>Subject: [IPk] Soluble & PZI mixture
>Date: Wed, 20 Sep 2000 18:00:37 +0100
>Dear John & Michael,
>Thank you both for coming back to my request regarding anyone with
>experience of the Soluble / Protamine Zinc mixture and please accept my
>apology for not getting back to you sooner. I was just curious and will 
>you why.
>I was admitted to the local hospital on the on 1st March 1951 and found 
>I had become diabetic at the age of 14. I was immediately put onto soluble
>insulin. After being an inpatient for 3 weeks, the sister told me one
>evening that I could go home the next day. However, the following morning
>the Dr. came and told me that he was going to keep me for another week as 
>wanted to try me on a new insulin that would mean just one injection a day
>instead of 2. If only one could look into the future I would have said,
>forget that I am going home today.
>Any way, after being in the hospital for a month I went home and started my
>new life with one injection a day of the above mixture. All was okay for
>about 6 years and then it started to go very wrong. I lost weight rapidly,
>my urine tests were very erratic, I had pains in my legs and feet at night
>and was very uncomfortable in the tummy. This continued for at least 12
>months by which time I was extremely thin and looking very sick. It was
>obvious to all around me that unless something was done soon, then I would
>not live for much longer. Unfortunately, nothing was done locally.
>(I found out later that they thought there was something else wrong with me
>and that I was going to die within a coup;e of years).
>Naturally, my parents were very concerned but no-one really knew what to do
>for the best. Eventually, arrangements were made for me to stay with an 
>& uncle in London and a friend managed to get me an out-patient appointment
>at the London Hospital. However, before that appointment was due, one
>weekend I became very ill and was taken to the hospital emergency dept. I
>was offered the opportunity to be sent back home by ambulance or  admitted,
>I chose the latter. Two days later the specialist came to me and said "I
>gave you enough of your insulin to kill about 10 ordinary people yesterday,
>yet it had no effect. Do you mind if I try you on something else? I don't
>like what you are on and NEVER use it!" I told him that the insulin he had
>administered the previous day had given me the most terrible headache but
>that I was in his hands and would be happy to try anything he suggested. I
>was 21 at the time and weighed just over 6 stone. I stayed there 2 months
>and by that  time my weight had increased to around 8 stone. They invited 
>to come back for regular check ups, I did that for the next 32 years.The
>specialist was Dr. Bomford and he used Amorphous semi-lente. I remained on
>this for 18 years. While I was there they also dissolved a cataract that 
>developed in my left eye..
>When I returned home, my G.P. pooh-poohed the whole matter and sent me to
>see the local specialist, I went just once but to be fair he said, "Well 
>have seen some far more eminent people than ourselves and they have
>obviously done you the power of good".
>To cut the story short, I knew two ladies who also attended the local 
>and who were on the soluble / PZI mixture, both died within 2 years.
>In 1972 I was in the eye ward of the London Hospital for a cataract 
>One morning the sister came to me and asked if would go and talk to a young
>diabetic man who was in for an eye operation, he had  just had a rather
>nasty hypo and was very upset. I chatted to him for a little while and 
>out that he had been very erratic and unwell for quite sometime. I gathered
>from the symptoms he was describing that he was on the Soluble / PZI
>mixture, so I said to him, "Don't tell me what insulin you are on, let me
>tell you". When I told him that he was on the dreaded mixture he said "how
>the blxxdy hell do you know", I told him, because I have experienced the
>same symptoms. I advised him that when he next saw his specialist to ask 
>a change of insulin, he said that he couldn't possibly do that. I tried 
>to persuade him as we chatted on for sometime. I often wonder what became 
>Since those experiences I have considered this to be a killer mixture, yet
>you both seem to have used it for several years without trouble. So it was
>obviously suitable for some people's metabolism.
>Michael, I congratulate you for being on insulin for almost 60 years, in
>that time you must have had many different experiences and learnt an awful
>lot about diabetes and how to cope and live with it.
>Many thanks again to you both and I wish you good health and happiness into
>the future. And the same for everyone on the list. My apology that this is
>rather long.
>for HELP or to subscribe/unsubscribe, contact: HELP@insulin-pumpers.org
>help SUPPORT Insulin Pumpers http://www.insulin-pumpers.org/donate.shtml

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