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Re: [IPk] Lyumjev insulin



Thanks! Sounds a highly unpleasant thing to be putting in our bodies!
Di


 > On 18 Nov 2020, at 16:10, Tim Street
<email @ redacted> wrote:
> 
> Apparently:
> 
> Treprostinil is a prostacyclin analogue which stimulates prostacyclin
> receptors in skin nociceptor terminals, resulting in pain and cutaneous
> hypersensitivity, for which current pain remedies have limited effect.
> 
> 
> 
> From this paper:
> https://watermark.silverchair.com/aet308.pdf?token=AQECAHi208BE49Ooan9kkh
> W_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAApwwggKYBgkqhkiG9w0BBwagggKJMIIChQIBADCCAn4GCSq
> GSIb3DQEHATAeBglghkgBZQMEAS4wEQQMYiN6abdt_-_AlzegAgEQgIICT9LlPwSH6o_RP4TqBK1f
> fLB90TRhjvdnKzkckC0e6ZQQgAgzvhzJPxbnxBrjjUDvbJJ4z7f0Cwsuv3sMCBjFAAY5Cxzd4QGGq
> wBXCWc79-2gSh_Uj69qWTKWxVDQ6lRgQwoWe315DHy9x_tRwSX2kEiZ86qwjcO_SYC64I9Og-PhwQ
> EZWhrljx_EXkbUzkphp5RjSMHB_-y8cojQogsG6JH6I_5P18vXal39CTNgd0ABmQBcgchHklMaynR
> c_7f7OVCYxPA14MgYoJDu6M5cm2mcMAO0DQL8FvS7Znrau1uTaA-08lfFCM01uNYwXZ62b6rzOsFf
> xYpHm7hu0j-2aJS18y2XbgDbPY-q56XMChW9hnCI9Bb1VlkpC_EbWHTnHNqXh-VkI-16LygWHt-NI
> zcQ7-nNwSmCX-01obOOOKmNaIXoVYytEcQuCyRGlzRkcx-1ruqiJRIyYiAY-yZOIdXGizNfVdv2eu
> Wl-h6wwpyx6EDfhdNoFkh2IZyjl7EQrblUP3ER4Xk57Um3bPWh8CKi-cKKhXr0nib3lpk5aCeZVDA
> _QIw1FHyJKo6y3psCcqTL71jUMgs84lKTyvlMF2RUPwgwslu-B7L7ur_sPJAYvYCwPVEnwTQq1nzQ
> MHLlxrdn9wO4hYaQ5SKupi5uVE2SGcq-rArBDmfJtRS8R-7PDHvoPqhbCQCqxducoJIHDhbWV2coa
> q3DvwosYppdrXkg1H0jydF6m0xzufPK4-44LoRQyAkSDGsGo3T_4qEvwitPi9XzObnDGfaa4N-Q_g
> 
> 
> 
> The paper looks at using a Capsaicin patch as an analgesic to relieve the
> site pain.
> 
> 
> 
> Sent from Mail for Windows 10
> 
> 
> 
> From: Diana G Maynard
> Sent: 18 November 2020 15:59
> To: email @ redacted
> S ubject: Re: [IPk] Lyumjev insulin
> 
> 
> 
> thatbs really interesting - whatbs the scientific explanation for the
> pain?
> 
> Di
> 
> 
> 
>> On 18 Nov 2020, at 15:51, Tim Street
> 
> <email @ redacted> wrote:
> 
>> 
> 
>> I've used it and so have many others across Europe. What I've found is
> 
>> detailed at https://www.diabettech.com/Lyumjev
> 
>> 
> 
>> If that's tldr, then I'd sum it up as the first week was awful and it
> 
>> didn't work at all well and hurt like hell, with me waking up when I
> rolled
> 
>> on to the infusion site in the night due to the pain.B  I switched to
> mixing
> 
>> it 50:50 with Fiasp, which worked well and removed pain while retaining
> 
>> relatively fast speed.
> 
>> 
> 
>> Others have seen a range of issues from nothing to similar pain. A
> number
> 
>> have stopped because of the pain.
> 
>> 
> 
>> Move forward 2.5 months and I was able to switch back and now I'm on
> 100%
> 
>> Lyumjev with no pain.B  It works really quickly and I've had great TIR
> of
> 
>> 90% for the last month (bear in mind I'm using an open source closed
> loop).
> 
>> 
> 
>> The key additive that makes it faster is Treprostinil and it's normally
> 
>> used subcutaneously for Pulmonary Hypertension. The papers I've found
> on
> 
>> that say that it usually causes site pain for a couple of months when
> used
> 
>> in that fashion which eventually subsides, so its no surprise that a
> lot of
> 
>> people have reported site pain.
> 
>> 
> 
>> Tim Street
> 
>> 
> 
>> +44 (0) 7740 051460
> 
>> 
> 
>> On Wed, 18 Nov 2020, 12:57 Ken Tieszen, <
> 
>> email @ redacted> wrote:
> 
>> 
> 
>>> I have decided to change from humalog to lyumjev insulin, and wonder
> if
> 
>>> anyone
> 
>>> else has tried or is using this insulin. Lyumjev is the new type of
> lispro
> 
>>> that
> 
>>> contains citrate which helps to speed absorption. NICE reports that it
> is
> 
>>> 11 min
> 
>>> quicker than humalog (lispro) and duration is about 40 min shorter. I
> am
> 
>>> hoping
> 
>>> that it will help me better control post-prandial glucose levels.Ken
> 
>>> .
> 
>>> Donate with every purchase http://smile.amazon.com/
> 
>>> (select your charity = Insulin Pumpers)
> 
>> .
> 
>> Donate with every purchase http://smile.amazon.com/
> 
>> (select your charity = Insulin Pumpers)
> 
> 
> Donate with every purchase http://smile.amazon.com/
> 
> (select your charity = Insulin Pumpers)
> 
> 
> .
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