[Previous Months][Date Index][Thread Index][Join - Register][Login]
[Message Prev][Message Next][Thread Prev][Thread Next]

Re: [IPk] Dormant Insulin

Hi Di,

sounds like a great idea.  I have often wondered about how exactly insulin 
works.  Wouldn't it be great if the insulin floating around in our bodies 
only started working once there was sugar to attach itself too?

Fascinating times....


>From: Diana Maynard <email @ redacted>
>Reply-To: email @ redacted
>To: email @ redacted
>Subject: [IPk] Dormant Insulin
>Date: Thu, 15 Nov 2001 10:51:45 +0000
>Has anyone heard about this? It's a new one to me. Sounds like a good idea,
>at least.
>Insulin Altered to Lie Dormant Until Needed
>Scientists in California have developed a way to modify insulin that may
>allow diabetics to store the sugar-processing hormone in their bodies until
>it is needed.
>People with type 1, or insulin-dependent, diabetes produce little or no
>insulin, a hormone that regulates the amount of sugar in the blood. To
>maintain healthy levels of blood sugar, they must take insulin, often by
>injection. Another option is to use an insulin pump, a device implanted in
>the body that provides a continuous supply of the hormone.
>Dr. Jerrold M. Olefsky of the University of California at San Diego and
>colleagues are working on an insulin delivery technique that could one day
>provide a more convenient way for people with diabetes to maintain their
>blood sugar levels. Their findings are published in the November 20th issue
>of the Proceedings of the National Academy of Sciences ( news
>web sites
>National%20Academy%20of%20Sciences&cs=nw> ).
>The researchers modified insulin so that it is dormant until activated by
>38C2, a type of protein called a catalytic aldolase antibody. The idea is
>that a diabetic person could take insulin, which would then be stored in 
>body until a drug containing the antibody activated the hormone.
>In laboratory tests, the altered form of insulin was much less effective at
>processing sugar. The modified insulin was 90% less likely to bind to
>insulin receptors. And its ability to process sugar was reduced by 96%.
>But when Olefsky's team added the antibody, the properties of the modified
>insulin were restored to normal. When the researchers tested the system in
>rats, they achieved similar results.
>According to Olefsky and his colleagues, the approach ``may represent a new
>avenue of therapeutics'' for treating diabetes.
>for HELP or to subscribe/unsubscribe, contact: HELP@insulin-pumpers.org
>help SUPPORT Insulin Pumpers http://www.insulin-pumpers.org/donate.shtml

Get your FREE download of MSN Explorer at http://explorer.msn.com/intl.asp
for HELP or to subscribe/unsubscribe, contact: HELP@insulin-pumpers.org
help SUPPORT Insulin Pumpers http://www.insulin-pumpers.org/donate.shtml