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[IPk] the last bit of insulin

This sounds a bit weird, but i've found that when I get down to the
very last bit of insulin in the reservoir, it doesn't appear to work
properly (ie my Bg goes up). 
it's not a problem - I just know to refill before it gets really low -
but I can't figure out WHY.
It;s not the site as when I refill the cartridge it's fine again, and
when I check it, there's still insulin coming out.
Anyone have any ideas on this one?

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