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Re: [IPk] Re: Question for Teresa

Hi Di,

The difference to the reservoir being in the pump at that point is
that it is in the pump only for a limited number of days (however you
run things), whereas if you prepare reservoirs in advance then they
are there for much longer - my rather vague not very scientific
thinking is that once you have pierced the seal of the vial, that is
no longer 100% sterile, but hopefully with reasonable hygiene, nothing
will get in, and once you draw up insulin into the reservoir and do
assorted manoeuvres to get out air bubbles, again a very slight
additional chance of contamination, even covered by little cover thing
or connection to tubing, and the more days elapse, the more chance
that any possible contamination may develop further. I agree that
these are very small risks, and I wouldn't lose sleep over them.

I agree with you about not putting insulin in and out of the fridge,
not only because of bubbles, but also wondering if it would do more to
denature the molecules - that was my question in previous email - in
the hope that someone out there has an answer.


On 30 June 2011 11:51, Diana Maynard <email @ redacted> wrote:
> HI Nanette
> If you attach the tubing to the reservoir before you store it (which is what
> I do), then there is no way anything can get in, so I don't see an issue
> (it's no different to the reservoir being in the pump at that point.
> I don't bother storing it in the fridge once I've filled the reservoir - no
> need as it keeps for long enough at room temp and as you say, there could be
> bubble issues if you start making it colder and then warming it up again.
> Di
> On 30/06/11 08:27, Nanette Freedman wrote:
>> I would be very reluctant to fill reservoirs in advance and keep them
>> either in the refrigerator or at room temperature since apart from all
>> the reasons given by others, sterile technique is not used when
>> filling the reservoirs - I've never heard of risk of infection from
>> this but don't want to find out the hard way. Also in all this talk
>> about storing insulin in the fridge or at room temp, does anyone know
>> whether alterations in temperature caused by having the insulin out of
>> the fridge for significant time to reach room temperature (I would not
>> consider 15 minutes which someone else mentioned to be enough) and
>> then returning it to the fridge are damaging to the molecules.
>> Something in my intuition about behaviour of biological molecules
>> makes me prefer to leave the insulin outside the fridge at room temp
>> but definitely away from direct sunshine once I have taken it out -
>> but I would love to know if there is any scientific basis to my hunch.
> .
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