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Re: [IPk] severe hypo or not?

Very interesting indeed
This does seem to be the explination concerning a couple of hypo's Les has
experienced, he's been functioning but his bloods at been down in the 1's, but
I got him to eat with a lot of ease then a follow up test will say he's mid to
high 2's, but he goes out at this point!  But Jackie's explination makes sense
if his spinal fluid glucose levels are lagging behind then this makes total
sense of the flow of his hypo..

I hope that David is feeling better...  Not sure if a fit while hypo would be
similar to an epiletic fit, where the body uses a lot of engery up, I know
that epiletic even though they've come around and out of the fit it can take
quite a while to fully recover phsyically from it..  One chap I knew depending
on the fit it could take another day or so for him to feel right and fully
recovered, but as I said I don't know if a diabetic fit could be similar in
vien to the epiletic!

From: Jackie Jacombs <email @ redacted>
To: email @ redacted
Sent: Tuesday, 21 June 2011, 11:26
Subject: RE: [IPk] severe hypo or not?

This info came from something I read some years ago, by  Dr.David Schwartz
who is  a paediatric endocrinologist.

Kind regards
Jackie J

-----Original Message-----
From: email @ redacted [mailto:email @ redacted] On Behalf
Of Diana Maynard
Sent: 21 June 2011 10:36
To: email @ redacted
Subject: Re: [IPk] severe hypo or not?

HI Jackie
That's interesting, I never knew about the spinal fluid!

On 21/06/11 10:27, Jackie Jacombs wrote:
> Hi Brenda
> Is David any better today?
> It maybe that although the finger stick reading was 3.4 mmols several
> minutes
> after the seizure, the glucose level in the brain could well have been
> previously.
> Adrenalin released as the hypo was getting worse would also raise the BG
> levels.
> The first hormone released is adrenaline; this produces symptoms like a
> pounding heart rate,
> Feeling shaky, sick and sweaty.  Adrenalin is released to enable the body
> respond to stress.
> The hormone glucagon would also be released to "tell" the liver to release
> store of glycogen.
> If someone has just had a severe hypo and/or has been exercising the
> glycogen stores maybe
> depleted. So giving glucagon would not always work. You would need to  IV
> glucose very quickly.
> After a hypo the BG levels should be left to run a little higher than
> and glucose/carbs should be eaten to restock the liver stores.
> The  major fuel for energy for the brain (and the rest of the body) is
> glucose. The glucose is carried by the various blood vessels to the brain
> where it must then leave the circulation and enter into the spinal fluid
> which "bathes" the brain. Most of the time, the spinal fluid glucose
> concentration is really close to the glucose concentration in the blood
> stream. But, under the right/wrong set of circumstances, there can be a
> "delay" in the filtration and recovery/change of spinal fluid glucose
> relative to the blood glucose level. We sort of measure the blood
> glucose as a surrogate marker for the spinal fluid glucose because you
> can't get spinal fluid easily or without harm!!
> The fact that there can be a time lag between blood glucose levels and
> spinal fluid/brain glucose is one of the reasons for sometimes finding
> "normal" BG levels but feeling like crap and shaking from the lack of
> glucose. This time- lag and the blood brain barrier is also the reason why
> sometimes someone can have an extremely low reading on the meter but look
> and feel fine, though quite often as you start to treat the hypo, the
> symptoms begin to "catch up" as the spinal fluid bathing the brain is
> getting low in glucose.
> Kind regards
> Jackie J
> -----Original Message-----
> From: email @ redacted [mailto:email @ redacted] On
> Of email @ redacted
> Sent: 20 June 2011 10:57
> To: email @ redacted
> Subject: RE: [IPk] severe hypo or not?
> Hi Di
> He did have a seizure when he was on holiday in Bulgaria a few years ago
> and I have been told that it took 12-24 hours for him to be fully
> coherent. However, the 24 hours is now up and the second seizure is
> obviously possibly very significant.
> The 3.4 reading was immediately after the seizure and I did think that
> it could possibly have been lower when he seized and he had rebounded -
> can't remember the exact terminology for all this because I'm not
> thinking straight! The previous occasion also occurred in the morning
> before he got up so I would really class it as a nightime hypo, although
> not sure if that makes a difference orr not.
> Brenda, mum of David, 22
> .
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