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[IPk] RE: substances in insulin


A few small items for you off the top of my head:

Apidra (insulin glulisine), the new rapid-acting insulin analogue from 
Sanofi-Aventis, cannot be mixed with any insulins containing zinc or it will 
act like Actrapid when injected. Thus Sanofi-Aventis is going to great 
lengths to prevent people attempting to mix (in the same syringe) Apidra 
with any insulins that contain zinc. Lantus contains zinc, by the way.

Lilly's recombinant DNA (rDNA) process involves E. coli bacteria. Active 
bacteria are not in the insulin product, though! There's a special 
non-disease strain of E. coli that is used in biotech products. Novo 
Nordisk's rDNA process involves baker's yeast (S. cerevisiae).

A lot of the more exotic animal ingredients of insulins of yore don't apply 
in rDNA production methods, but the steps of rDNA technology are rather 

Of course all insulins on the market today contain preservatives to keep 
them from going off and some people have reactions to certain preservatives. 
Interestingly, I have run across a few journal articles attributing 
irritation at the pump infusion site to an immune response to such 
preservatives, but not the kind of response you might expect. In some 
people, the preservatives cause the immune system not to kill bacteria 
around the infusion site, allowing irritation and even infection to develop. 
Yet another great reason to change our infusion sets on time!!!

Type 1 13 years; MiniMed pumper 7.5 years; Animas pumper 2 years 5 months

----Original Message Follows----
From: "Elizabeth O'Shea" <email @ redacted>
Reply-To: email @ redacted
To: <email @ redacted>
Subject: substances in insulin was RE: [IPk] my diabetic son
Date: Thu, 8 Jun 2006 13:12:50 +0100

Does anyone know of other strange substances used in insulin production.
Melissa, does your extensive knowledge of diabetes stretch this far?

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