[Previous Months][Date Index][Thread Index][Join - Register][Login]
[Message Prev][Message Next][Thread Prev][Thread Next]

[IPk] re :inhaled insulin

Hi this may be of intrest to those who were wondering about inhaled insulin.
Not my cup of tea prefer my pump.
Inhaled Insulin as Effective as Injections

By Pippa Wysong

TORONTO, Jun 27 (Reuters Health) - Results of a multicenter phase II study
show that insulin in a formulation that can be inhaled results in glycemic
control comparable to that achieved with conventional subcutaneous

The findings were presented by Dr. William Cefalu, of the University of
Vermont, at the 82nd annual meeting of the Endocrine Society. He also
announced that recruitment has already begun for a large phase III trial
using inhaled insulin.

A total of 70 patients with type 1 and type 2 diabetes at nine centers were
randomized in an open-label study to use either the inhaled insulin before
meals, with an insulin injection at bedtime, or their usual subcutaneous
injections or oral hypoglycemic medication. There was a 4-week lead-in
period to the study, then a 12-week treatment period.

Both groups performed home glucose monitoring four times daily, had weekly
insulin dose adjustment, and had preprandial glucose targets of 100 mg/dL to
160 mg/dL.

The inhalation device comprises a clear plastic cylinder about 10 inches
tall, the base of which holds a container of compressed air. Insulin is kept
in small, single-dose sachets that are inserted into the device, punctured,
and then aerosolized by the compressed air. The patient inhales once through
a mouthpiece.

Each sachet contains either 1 mg or 3 mg of drug, with the 1-mg sachet being
comparable to a 3-unit dose delivered by syringe, Dr. Cefalu said.

It was found that the inhaled insulin "worked similarly well as subcutaneous
injections," he said. It even proved to have an advantage when used in
patients with type 2 diabetes who had been on oral agents only.

for HELP or to subscribe/unsubscribe, contact: HELP@insulin-pumpers.org
help SUPPORT Insulin Pumpers http://www.insulin-pumpers.org/donate.shtml