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Re: longacting insulins was Re: [IPk] Glucowatch by Cygnus


thank you for your info below,  It really sounds like you have to do a lot 
of experimentation, lots of testing, and the patience to figure out what 
works for you.

Thanks again,


>From: "Elizabeth OShea" <email @ redacted>
>Reply-To: email @ redacted
>To: email @ redacted
>Subject: Re: longacting insulins was Re: [IPk] Glucowatch by Cygnus
>Date: Tue, 22 Jan 2002 01:29:14 +0000
>>How did you come up with your 3pm and 9pm shots?
>Hi Ingrid -
>It happened through experimentation and, frankly, having more time in the
>year after I was diagnosed than I do now. I got started off on a bedtime
>shot of ultralente, which is called Zn in these parts (except I'm in
>Illinois as I type, so it's not, but you know what I mean). After a few
>weeks, I told my diabetes nurse that it seemed to not give me coverage in
>the evening, and she looked at my numbers and suggested I add a 3 unit
>booster at noon. Things improved.
>Eventually the 'bedtime' shot got moved to 10pm, because I was staying up
>when I was exhausted to have my shot at 'bedtime', which is generally 11pm.
>But I realised the important thing was to have the insulin at the same time
>everyday, so I moved that shot to 10pm. And I think, but I'm not certain
>without checking records, that the 12pm shot started creeping up toward 3pm
>as I checked my BGs against the action curve of Zn (begins work 4 hours
>after injection, hits peak at 10 hours, declines at 18. Claimed to be in 
>body for up to 36 hours, but it didn't do much for me after 18 hours).
>My next big challenge was night time hypos. At this stage I was on the 
>dose at 10pm, booster at 3pm. I was living in Dundalk, the cesspit of
>backward diabetes thinking (but a nice town), so I had to sort it myself or
>suffer. And, looking at my numbers, I had the radical idea that perhaps 
>I needed to do was have the larger shot at 3pm and the booster at 10pm. So 
>did. And viola, no more frequent night time hypos.
>Now, of course, you're not supposed to do anything like this without
>consulting your medical team. But what passed for my diabetes carers were
>either overworked, understaffed, and inexperienced, or a scandal to the
>medical profession.
>The important thing to remember if you're experimenting is that a) you're
>responsible if anything goes wrong and b) you have to be able to climb out
>of any pit you dig for yourself. Generally, that climbing means going back
>to the regime you were on before.
>That's the long tale. The short tale is: make the action profile of your
>insulin match what your body needs. It may be an injection schedule no one
>has seen before, but what's important is that it works.
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