[IPn] T1 diabetes reversed by stem cell therapy
Hello Pumpers,
Don't get your hopes up to far YET with the subject line. Yes, it is
very cool and it works but there is a long way to go. I suspect there
are some immune suppression issues that are not mentioned in the
article.
see: http://www.biomedcentral.com/1741-7015/10/3/abstract
The whole article is here:
http://www.biomedcentral.com/content/pdf/1741-7015-10-3.pdf
Michael
=============== short version ==================
Methods
We developed a procedure for Stem Cell Educator therapy in which a
patient's blood is circulated through a closed-loop system that
separate lymphocytes from the whole blood and briefly co-cultures
them with adherent CB-SCs before returning them to the patient's
circulation. In an open-label, phase1/phase 2 study, patients (n =
15) with T1D received one treatment with the Stem Cell Educator.
Median age was 29 years (range, 15 to 41), and median diabetic
history was 8 years (range, 1 to 21).
Results
Stem Cell Educator therapy was well tolerated in all participants
with minimal pain from two venipunctures and no adverse events. Stem
Cell Educator therapy can markedly improve C-peptide levels, reduce
the median glycated hemoglobin A1C (HbA1C) values, and decrease the
median daily dose of insulin in patients with some residual beta cell
function (n = 6) and patients with no residual pancreatic islet beta
cell function (n = 6). Treatment also produced an increase in basal
and glucose-stimulated C-peptide levels through 40 weeks. However,
participants in the Control Group (n = 3) did not exhibit significant
change at any follow-up. Individuals who received Stem Cell Educator
therapy exhibited increased expression of costimulating molecules
(specifically, CD28 and ICOS), increases in the number of
CD4+CD25+Foxp3+ Tregs, and restoration of Th1/Th2/Th3 cytokine
balance.
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