RE: [IPk] What is MODY?
Here is a better explanation about MODY
Maturity-Onset Diabetes of the Young (MODY)
A form of diabetes characterised by early age of onset (usually less than 25
years of age), autosomal dominant inheritance (that is, it is inherited by
50% of a parent's children) with diabetes in at least 2 generations of the
patient's family. MODY diabetes that can often be controlled with meal
planning or diabetes pills, at least in the early stages of diabetes. It
differs from type 2 diabetes in that patients have a defect in insulin
secretion or glucose metabolism, and are not resistant to insulin. MODY
accounts for about 2% of diabetes worldwide and 6 genes have so far been
found that cause MODY, although not all MODY patients have one of these
genes. Because MODY runs in families, it is useful for studying diabetes
genes and has given researchers useful information about how insulin is
produced and regulated by the pancreas.
One of the main differences seems to be that there isn't a problem with
resistance to insulin and the genetic link is very strong. Whereas it is
believed that if you have a family history of type 2, keeping the weight off
may prevent the diabetes from developing.
Don't forget to mention LADA as this type of diabetes is often found in
usually slim, young to middle aged adults and is frequently misdiagnosed as
type 2. This type of diabetes usually needs to be treated with insulin and
not type 2 meds. There is usually no insulin resistance and often only a
small amount of insulin is needed for many years
More about MODY
More about LADA
> -----Original Message-----
> From: email @ redacted [mailto:email @ redacted]On
> Behalf Of John Neale
> Sent: 07 February 2005 12:09
> To: email @ redacted
> Subject: RE: [IPk] What is MODY?
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> >You asked about the difference between MODY (Mature onset
> diabetes of youth)
> >and Type 2 diabetes in children. MODY is a gene linked condition
> >dominant inheritance, which so far at least 7 different types linked to
> >different genes. Some types will need minimal or no treatment
> whilst other
> >genetic types are linked to a high risk of complications, therefore
> >requiring very tight control. Children are normally normal
> weight and have
> >diabetes in other generations within the family. For more info:
> >Type 2 diabetes is the same as that found in older people, and
> is primarily
> >due to obesity (and some inheritance issues as well)- hence all
> the recent
> >press coverage. This type of diabetes is on the increase across
> the world -
> >is also linked to something called the Metabolic Syndrome.
> Thanks, Jackie.
> Am I 20 years out of date of something? I thought diabetes was
> classified as two types: Type 1 and Type 2. Type 1 you produce little
> or no insulin, and must take it artificially to survive. Type 2 your
> body produces plenty of insulin, but can't use it properly, and
> insulin production may ultimately fail, leading to the need for
> insulin injections etc.
> I associate gestational diabetes with Type 2 diabetes - plenty of
> insulin produced, but not used effectively.
> Type 1 can have many causes - autoimmune destruction of insulin
> producing cells, surgical removal of pancreas etc.
> Type 2 has even more causes - in some, obesity can be caused by Type
> 2 diabetes, or Type 2 be caused by obesity, or the two go hand in
> hand. Some are normal or below weight at diagnosis.
> Is MODY a type of Type 2 diabetes? Or is it, say, Type 3 diabetes?
> Gently confused -
> PS We've been asked if the glossary of diabetes terms on our website
> <http://www.insulin-pumpers.org.uk/glossary> can be used in a
> forthcoming parliamentary report on diabetes. This is based on the
> gathering of opinions at <http://www.tellparliament.net/diabetes>
> which happened last month. I'm trying to clear out any nonsense from
> the glossary, and add any new terms: it's not been updated for a
> while. If people could look at the glossary and use the feedback box
> at the bottom with any suggestions, that would be much appreciated.
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