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Re: [IPk] Glargine / glucose sensing as a tool

I am following this discussion re glargine with interest - I am not yet 
pumping and would like to try glargine before I commit to a pump.


when will it be available in the UK?



>From: John Neale <email @ redacted>
>Reply-To: email @ redacted
>To: email @ redacted
>Subject: Re: [IPk] Glargine / glucose sensing as a tool
>Date: Sat, 1 Dec 2001 00:23:54 +0100
>I happen to be using a constant basal rate at the moment, and it's giving
>me pretty good results that I am happy with. I've been watching this new
>glargine with great interest... if it will give me a reliable constant
>basal rate, I would happily put my pump away. And if I needed a different
>day and night rate, I'm sure a twice daily glargine injection could achieve
>Lets face it: wearing a pump is a fiddle and an annoyance. I only do it
>because it gives me great bg results, no nighttime hypos and frees me from
>forced eating - which on balance is a pretty good deal.
>But two things worry me about glargine:
>How reliable is it from day to day? If you look at the published medical
>literature on long acting insulins, there is a remarkable variability from
>day to day as to how much of what you inject actually dissolves and gets
>into your blood. That limits how tightly you can control your bg.
>And is it really flat in its release? If you inject it once a day, how on
>earth does it know when to stop? Or is there a vague period when
>yesterday's injection hands over to today's injection - and your basal rate
>doubles or halves for an hour? Basically I'm not convinced by those lovely
>smooth graphs...
>mailto:email @ redacted
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