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Re: [IPk] Re: insulin sensitivity : pulses or continuous delivery ?

A study was published by Levy-Marchal and Zinman in Diabetes Care which addressed this very issue .'Overnight Metabolic Control with pulsed Intermittent insulin versus continuous Subcutaneous Insulin Infusion '

ie / Is it better to give insulin continually or in pulses at varying intervals ?  

Time intervals between pulses was 30 , 60 and 120 minutes .
The results showed that the plasma glucose levels were the same whether the insulin was given continuously or intermittently and in both cases they remained stable .
Free insulin levels were the same with continuous and pulsed insulin .

The study conclusion was that the similarity in metabolic control between the 2 groups demonstrates the wide physiological limits for sc basal insulin replacement .Both pulses and continual trickles of insulin provided the same results in terms of control and free insulin levels .

Nanette ,
when disconnecting from the pump for baths and showers we recommend that you take the missed insulin via a small bolus if required .
After disconnecting for sport we recommend that you check your blood glucose and then decide if the missed insulin is required ; maybe not depending on level and duration of activity .

Best wishes to all
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