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RE: [IPk] Fwd: Non-member submission from ["Peter Jennings" <email @ redacted>]



interesting.
i am curious if any here ever had a virus called cocsackie (spelling?) i 
have read that as some
illness can damage organs that that virus has been known to shut down the 
pancreas.i had it as a child and at age 12 was diagnoised with 
diabetes.thanks,

sharon

-----Original Message-----
From:	Diana Maynard [SMTP:email @ redacted]
Sent:	Wednesday, August 16, 2000 6:45 AM
To:	email @ redacted
Subject:	[IPk] Fwd: Non-member submission from ["Peter Jennings" 
<email @ redacted>]

>From email @ redacted  Wed Aug 16 03:35:23 2000
From: "Peter Jennings" <email @ redacted>
To: <email @ redacted>
Subject: Possible Link in Onset of Type 1 Diabetes Discovered
Date: Wed, 16 Aug 2000 11:35:42 +0100

Hello Everyone,

Here's some interesting & exciting news from Canada.


Pete Jennings
MiniMed


Possible Link in Onset of Type 1 Diabetes Discovered By Canadian 
Researchers
and Funded by Juvenile Diabetes Foundation

August 11, 2000 12:00am
Source: PR Newswire
NEW YORK, Aug. 10 /PRNewswire/ via NewsEdge Corporation -- Researchers at
the University of Calgary have made a significant step towards 
understanding
the development of Type 1 diabetes, according to a study published in this
week's issue of the journal Nature. The study was funded by the Juvenile
Diabetes Foundation (JDF), and led by Pere Santamaria. M.D., Ph.D.,
Associate Professor of Microbiology and Infectious Diseases in at the
University of Calgary, with the participation of other researchers from
Calgary, Alberta and Vancouver, British Columbia in Canada and from Oxford,
England.
"Our study examined the way in which inflammation of the pancreas in Type 1
diabetes progresses to overt disease, and the role certain white blood 
cells
play in this process," says Santamaria. "This research is very exciting as
its principles can be applied to other autoimmune diseases in addition to
diabetes."
The study researched the way the body's white blood cells cause 
inflammation
and eventual destruction of islet cells -- the pancreatic cells responsible
for insulin production. The white blood cells recognize protein markers on
the surface of the islet cells, and this allows the white blood cells to
bind to and damage the islet cells. Dr. Santamaria's team discovered that
the population of white blood cells that bind most strongly become present
in increasing numbers with time. This process is referred to as "avidity
maturation." This select group of white blood cells that bind most strongly
to islet cells are the ones responsible for the progression from
inflammation to actual destruction of the insulin producing cells, 
resulting
in Type 1 diabetes.
The team found that by treating mice predisposed to diabetes with a protein
similar to the one recognized by these white blood cells, this maturation
process can be interrupted. Therefore, progression from inflammation of the
pancreatic cells to destruction can be avoided.
"This research suggests a strategy to block the onset of Type 1 diabetes in
at-risk individuals," said Robert Goldstein, M.D., Ph.D., Chief Scientific
Officer of JDF. "This is an important study for shedding light on the
mechanisms that control the development of autoimmunity and how it can be
blocked."
The study was funded by Juvenile Diabetes Foundation, the Canadian 
Institute
of Health Research (formerly the Medical Research Council of Canada) and 
the
Canadian Diabetes Association.
JDF is the world's leading nonprofit, nongovernmental funder of diabetes
research. It was founded in 1970 by parents of children with diabetes. 
JDF's
mission is to find a cure for diabetes and its complications through the
support of research, and since its inception has provided more than $326
million to diabetes research worldwide. For more information, visit JDF's
website: <http://www.jdf.org> or call 1-800-JDF-CURE.
SOURCE Juvenile Diabetes Foundation
/CONTACT: Julie Kimbrough, 212-479-7536, or email @ redacted
<mailto:email @ redacted>, or Randi Hoffman, 212-479-7502, or
email @ redacted <mailto:email @ redacted>, both of Juvenile Diabetes
Foundation/ /Web site: <http://www.jdf.org/>
FOR INFORMATION ONLY
Data and information is provided for informational purposes only, and is 
not
intended for trading purposes. Neither NewsEdge, eLogic nor any of its data
or content providers shall be liable for any errors or delays in the
content, or for any actions taken in reliance thereon.
 <<...OLE_Obj...>> Copyright ? 1999 <terms.asp>, NewsEdge Corporation
<http://www.newsedge.com>
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