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[IPk] Fwd: Non-member submission from ["Peter Jennings" <email @ redacted>]

>From email @ redacted  Wed Aug 16 03:35:23 2000
From: "Peter Jennings" <email @ redacted>
To: <email @ redacted>
Subject: Possible Link in Onset of Type 1 Diabetes Discovered
Date: Wed, 16 Aug 2000 11:35:42 +0100

Hello Everyone,

Here's some interesting & exciting news from Canada.

Pete Jennings

Possible Link in Onset of Type 1 Diabetes Discovered By Canadian Researchers
and Funded by Juvenile Diabetes Foundation

August 11, 2000 12:00am
Source: PR Newswire
NEW YORK, Aug. 10 /PRNewswire/ via NewsEdge Corporation -- Researchers at
the University of Calgary have made a significant step towards understanding
the development of Type 1 diabetes, according to a study published in this
week's issue of the journal Nature. The study was funded by the Juvenile
Diabetes Foundation (JDF), and led by Pere Santamaria. M.D., Ph.D.,
Associate Professor of Microbiology and Infectious Diseases in at the
University of Calgary, with the participation of other researchers from
Calgary, Alberta and Vancouver, British Columbia in Canada and from Oxford,
"Our study examined the way in which inflammation of the pancreas in Type 1
diabetes progresses to overt disease, and the role certain white blood cells
play in this process," says Santamaria. "This research is very exciting as
its principles can be applied to other autoimmune diseases in addition to
The study researched the way the body's white blood cells cause inflammation
and eventual destruction of islet cells -- the pancreatic cells responsible
for insulin production. The white blood cells recognize protein markers on
the surface of the islet cells, and this allows the white blood cells to
bind to and damage the islet cells. Dr. Santamaria's team discovered that
the population of white blood cells that bind most strongly become present
in increasing numbers with time. This process is referred to as "avidity
maturation." This select group of white blood cells that bind most strongly
to islet cells are the ones responsible for the progression from
inflammation to actual destruction of the insulin producing cells, resulting
in Type 1 diabetes.
The team found that by treating mice predisposed to diabetes with a protein
similar to the one recognized by these white blood cells, this maturation
process can be interrupted. Therefore, progression from inflammation of the
pancreatic cells to destruction can be avoided.
"This research suggests a strategy to block the onset of Type 1 diabetes in
at-risk individuals," said Robert Goldstein, M.D., Ph.D., Chief Scientific
Officer of JDF. "This is an important study for shedding light on the
mechanisms that control the development of autoimmunity and how it can be
The study was funded by Juvenile Diabetes Foundation, the Canadian Institute
of Health Research (formerly the Medical Research Council of Canada) and the
Canadian Diabetes Association.
JDF is the world's leading nonprofit, nongovernmental funder of diabetes
research. It was founded in 1970 by parents of children with diabetes. JDF's
mission is to find a cure for diabetes and its complications through the
support of research, and since its inception has provided more than $326
million to diabetes research worldwide. For more information, visit JDF's
website: <http://www.jdf.org> or call 1-800-JDF-CURE.
SOURCE Juvenile Diabetes Foundation
/CONTACT: Julie Kimbrough, 212-479-7536, or email @ redacted
<mailto:email @ redacted>, or Randi Hoffman, 212-479-7502, or
email @ redacted <mailto:email @ redacted>, both of Juvenile Diabetes
Foundation/ /Web site: <http://www.jdf.org/>
Data and information is provided for informational purposes only, and is not
intended for trading purposes. Neither NewsEdge, eLogic nor any of its data
or content providers shall be liable for any errors or delays in the
content, or for any actions taken in reliance thereon.
 <<...OLE_Obj...>> Copyright  1999 <terms.asp>, NewsEdge Corporation
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