[IPp] World-First Living Donor Transplant of Islet Cells a Success
- To: Rachel A <email @ redacted>
- Subject: [IPp] World-First Living Donor Transplant of Islet Cells a Success
- From: Rachel A <email @ redacted>
- Date: Thu, 3 Feb 2005 13:19:14 -0800 (PST)
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- Reply-To: email @ redacted
http://www.newswise.com/articles/view/509636/World-First Living Donor
Transplant of Islet Cells a SuccessLibraries
Medical News Keywords
DIABETES, EDMONTON PROTOCOL, ISLET CELLS
Available for logged-in reporters only
A University of Alberta surgeon, well known for his pioneering work in
developing the Edmonton Protocol treatment for diabetes, has taken another
important step in the fight against diabetes.
Newswise A University of Alberta and Capital Health surgeon, well known for
his pioneering work in developing the Edmonton Protocol treatment for diabetes,
has taken another important step in the fight against diabetes.
On January 19, at Kyoto University Hospital, Dr. Koichi Tanaka and Dr. James
Shapiro, along with a team of Japanese surgeons, removed part of a 56-year-old
woman's pancreas. Dr. Shinichi Masumoto then isolated the living islets in the
Kyoto Centre for Cell and Molecular Therapy. Under Dr. Shapiro's supervision,
the team then transplanted the insulin-producing cells into the woman's
27-year-old diabetic daughter.
The transplanted islets began producing insulin within minutes, explains Dr.
Shapiro. "The reason I'm so excited about this is because normally the Edmonton
Protocol is done with islets from brain-dead organ donors. Those islets are
often severely injured from cold storage, transport time and the pancreas is
severely damaged by toxins which circulate in the blood stream after brain
"Our expectation is that these islets from near-perfect organs will work
better, although it's too early to tell," he says.
The recipients use the same drugs to prevent organ rejection as are used in the
Dr. Shapiro was invited to participate in the operation in Kyoto, Japan, where
he originally did living donor liver transplant training with Dr. Tanaka. Dr.
Masumoto was previously based in Seattle and had been involved in Dr. Shapiro's
international trial of the Edmonton Protocol before returning to Japan. Dr.
Shapiro first suggested the idea of starting a living donor islet transplant
program in Kyoto while lecturing there three years ago. Cadaveric organ donors
are scarce in Japan, and living donation has very established roots in liver and
kidney transplantation there.
"Living donor islet transplants could allow many more desperate patients with
type 1 diabetes to get successful islet transplants," says Dr. Shapiro. "The
donor operation is relatively safe, but is not entirely devoid of serious
potential risk," he added.
A shortage of donor islet cells is the biggest obstacle preventing
implementation for all patients who need it, Shapiro added.
The mother of the diabetic daughter was in perfect health, while her daughter
has been on the cadaver donors transplant list since September 2004. Before the
surgery, the woman had been subject to severe low blood sugar coma attacks, and
her glucose control has been transformed by the transplant.
Photos available upon request
Rachel - email @ redacted/jracheln
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