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[IPp] Stomach and Uterine Cancer Risk Higher in Diabetes

Rachel ::(

Stomach and Uterine Cancer Risk Higher in Diabetes
Thu Dec 4, 1:09 PM ET
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 NEW YORK (Reuters Health) - Patients with type 1 diabetes have a higher risk of
cancer than the general population, a Swedish study shows. The excess risk is
most striking for malignancies of the stomach, cervix and the lining of the
uterus (endometrium).
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 Dr. Weimin Ye, at the Karolinska Institute in Stockholm and colleagues
evaluated data from the Swedish Inpatient Register and the Swedish Cancer
Register. They identified records for nearly 30,000 patients presumed to have
type 1 diabetes, based on hospitalization for diabetes before age 31.

 After discounting the first year after hospital discharge, there were 355 cases
of cancer among the diabetic patients. Relative to the general population, this
translated to an increased risk of 20 percent, the investigators report in the
Journal of the National Cancer Institute (news - web sites).

 For stomach cancer, the risk was not elevated until 15 years or more after the
initial hospitalization for diabetes, when the risk jumped by more than

 The increased risk for cervical cancer was 60 percent, and was similar before
and after 15 years' follow-up.

 During the first 14 years, diabetic women were 4.8 times more likely than the
general population to develop endometrial cancer. Thereafter, the risk was still
elevated, with an increased risk of more than twofold. In these women, the risk
may be related to the fact that they also had a higher rate of irregular
menstruation and fertility disorders, and where more likely to not have given

 The risk of cancer of the breast, colon and rectum, pancreas and kidney was
unaffected by type 1 diabetes status.

 Cancer risk is already known to be increased in patients with type 2 diabetes,
but the risks of specific cancers differ from those associated with type 1
diabetes, the authors point out. For example, pancreatic cancer rates are higher
among type 2 diabetes patients, which supports the theory that elevated insulin
level is the cause.

SOURCE: Journal of the National Cancer Institute, December 3, 2003. 

Rachel - email @ redacted

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