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Re: [IPp] Re: Switching a child to Novolog--follow-up



In plain English--yes I understand your explanation of the differences in
insulins.  Has there been or is there now a study using novolog in pumps,
with children?  My endo hasn't even mentioned novolog.  Mary
----- Original Message -----
From: "Michael" <email @ redacted>
To: <email @ redacted>
Sent: Thursday, April 11, 2002 3:28 PM
Subject: Re: [IPp] Re: Switching a child to Novolog--follow-up


> > In a message dated 4/10/2002 4:51:08 PM Mountain Daylight Time,
> > email @ redacted writes:
> >
> > > In plain english, the
> > >  insulin is reproduced by bacteria in a vat.  Insulin and insulin
> > >  analogs are comprised of very long chains of molecules. The insulin
> > >  analogs are essentially identical to "real" insulin except that one
> > >  (Novlog) or two (Humalog) of the molecules have been moved or
> > >  replaced.
> > >
> > >  In Humalog the amino acids at positions 28(lys) and 29(pro) on the
> > >  insulin B chain are reversed. In Novolog/NovoRapid, the amino acid
> > >  proline in position 28 of the insulin B chain is replace with a
> > >  molecule of aspartic.
> >
> > Michael, is there a reason why the molecules must be moved or
> > replaced?
>
> That is what gives both Novolog and Humalog the rapid absorption
> characteristic. Insulin in the vial is in  s spiral or "wound" state.
> In this state it is not absorbed by the body. When it enters the
> body, it proceedes to "unwind" into a linear form which is taken up
> by cells to metabolize glucose. The speed at which it "unwinds" in
> body tissue is changed when the aminio acids at B28, 29 are changed
> or moved.
>
> Michael
> email @ redacted
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