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Re: [IPp] Re: Switching a child to Novolog--follow-up

> In a message dated 4/10/2002 4:51:08 PM Mountain Daylight Time,
> email @ redacted writes:
> > In plain english, the
> >  insulin is reproduced by bacteria in a vat.  Insulin and insulin
> >  analogs are comprised of very long chains of molecules. The insulin
> >  analogs are essentially identical to "real" insulin except that one
> >  (Novlog) or two (Humalog) of the molecules have been moved or
> >  replaced.
> >  
> >  In Humalog the amino acids at positions 28(lys) and 29(pro) on the
> >  insulin B chain are reversed. In Novolog/NovoRapid, the amino acid
> >  proline in position 28 of the insulin B chain is replace with a
> >  molecule of aspartic.
> Michael, is there a reason why the molecules must be moved or
> replaced?

That is what gives both Novolog and Humalog the rapid absorption 
characteristic. Insulin in the vial is in  s spiral or "wound" state. 
In this state it is not absorbed by the body. When it enters the 
body, it proceedes to "unwind" into a linear form which is taken up 
by cells to metabolize glucose. The speed at which it "unwinds" in 
body tissue is changed when the aminio acids at B28, 29 are changed 
or moved.

email @ redacted
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