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Re: [IPu] help needed - insulin not working?

> Wondering if someone can shed light on my problem.  Have been pumping
> Humalog in Minimed 507c for over 4 years now and not had this problem
> before.  Pump is functioning, I can see insulin coming from tubing when
> I disconnect.  Pump keeps giving 'no delivery' alarm with bolus and
> basal sometimes too.  I use tender/silhouette and have changed the sites
> 6 times!!!!  I have tried using hip and leg area away from usual abdomen
> also. My BG are sky high as the site only lasts about 24 hours.  I have
> localised pain on insulin delivery and a hard ridge develops about 1cm
> out from site. I have also been using humalog by syringe during this
> time to try to prove levels away from pump issue.  Can one become
> reactive/allergic to insulin? Can the body decide to reject all foreign
> bodies not matter where? 

This type of thing has been reported by a number of insulin-analog 
users. Most have successfully switched brands and eliminated the 
problem. The various insulin-analogs have different molecular structure 
and the body reacts differently to them.

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