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[IPu] help needed - insulin not working?

Wondering if someone can shed light on my problem.  Have been pumping
Humalog in Minimed 507c for over 4 years now and not had this problem
before.  Pump is functioning, I can see insulin coming from tubing when I
disconnect.  Pump keeps giving 'no delivery' alarm with bolus and basal
sometimes too.  I use tender/silhouette and have changed the sites 6
times!!!!  I have tried using hip and leg area away from usual abdomen also.
My BG are sky high as the site only lasts about 24 hours.  I have localised
pain on insulin delivery and a hard ridge develops about 1cm out from site.
I have also been using humalog by syringe during this time to try to prove
levels away from pump issue.  Can one become reactive/allergic to insulin?
Can the body decide to reject all foreign bodies not matter where?  The sets
are not bent or scrunched when they come out.  I am getting fed up with this
battle.  Any ideas welcome.


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