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Re: [RE: [IP] Human insulins??]

By the way, there are two other varieties of insulin still available:

Lente - Lasts a total of about 24 hours, has a mild peak around 8-12 hours
after injection.  Has a slightly more pronounced peak than its counterpart,
Ultralente.  Its peak of activity is bell-curve shaped.

NPH - Also lasts about 24 hours in total, but has a much more dramatic peak
than other extended-duration insulins, peaking about 6 hours after injection. 
Its activity falls dramatically after peaking, so there is less of a "tail" of
unused insulin activity.

Of course, there are also the pre-mixed varieities, but every endo I've seen
(and I've moved cross-country twice) feels they are not appropriate for a
person with Type 1.

Scott Strumello <email @ redacted> wrote:

The truth is that in the United States market, virtually all insulins sold
today are made with recombinant DNA technology.  Pork and beef insulins are
much more costly to make, and the animal-based insulins sold here are imported
from countries where animal-based insulins are still manufactured and sold,
which are becoming fewer in number (Brazil, for example, still produces some
animal-based insulins).

Eli Lilly and Novo Nordisk no longer sell animal-based insulin products in the
U.S. (I think they stopped in 1999) because its much cheaper for them to
manufacture synthetic "human" insulins, it is more pure, and it is
theoretically a better replacement (although some people firmly believe

Just as an FYI, Eli Lilly uses E coli bacteria in its recomninant DNA
production, while Novo Nordisk uses a baker's yeast derivative.  I'm not sure
what Aventis uses.  Some patients experienced allergic reactions when
switching from animal to synthetic human insulins, but some doctors feel it
was due more to the agent used in recombinant DNA production (bacteria or
yeast) than it was to the composition of the insulin itself.


Dx'd Type 1 9/1976 at age 7; pumping with Animas R1000 since 6/2002 at age 33

Date: Wed, 1 Oct 2003 15:38:08 EDT
From: email @ redacted
Subject: [IP] Human insulins??

I have a girlfriend whose 13 year old son had his first fasting blood glucose
test today.  It was 282!  I have had diabetes so long that for myself I do not
pay much attention to which insulins are true "human" made with recombinant
DNA technology and others are pork products somehow changed to make our bodies
"think" they are human.

I figure that he will probably have his first insulin shot in about 3 hours
and I don't want him to have to deal with any antibody issue.  I believe the
current, non pump insulins are:

Novalog or Humalog--very short acting insulins
Velosulin or Regular-short acting insulins
Lispro - approximately a 24 hour insulin-should mimic basal rates
Ultralente - usually lasts 36 or so hours.

I think they should try Novalog or Humalog and Lispro, but I do not know 
 about the human factor, and of course, these are only my thoughts and he and
his family will have to follow the doctor's advice and instructions.

Cee Dee
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