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[IP] Nighttime Blood Pressure Gives Clue to Kidney Risk

>From JDRF

Researchers have discovered an early warning sign for diabetic nephropathy
or kidney disease, the dangerous complication of diabetes that can progress
to kidney failure, requiring dialysis or kidney transplant for survival.
Normally, a persons systolic blood pressure dips slightly overnight before
rising again in the morning hours. However, many patients with type 1
diabetes do not show this overnight drop. Based on a study monitoring 75
adolescents and young adults with type 1 diabetes, scientists at the
University of Valencia in Spain and Northwestern University report in the
September 12 New England Journal of Medicine that the study subjects whose
blood pressure did not dip during nighttime are more likely to develop a
condition called microalbuminuria-accumulation of the blood protein albumin
in the urine, which is an early indicator of nephropathy. They suggest that
the higher level of nighttime blood pressure may play an important role in
the development of diabetic nephropathy and may serve as the earliest
indicator that someone with type 1 diabetes is at high risk for the
condition. Currently, urine microalbumin tests can detect early kidney
disease, but at a point when substantial damage to the organ has already
occurred. Julie Ingelfinger, an editor of the journal, wrote in an
accompanying editorial that these findings, if confirmed, could argue for
giving blood pressure drugs to type 1 diabetes patients who dont show a
relative nighttime decrease-even if overall blood pressure is at normal
levels during other periods. She added, Additional studies with long-term
follow-up will be needed to learn whether these observations can be
generalized to a larger group of patients.

To read the abstract of this study, click below:
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