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RE: [IP] RE:Type 2



Barbara,

I'd like to ask you about something I've wondered about. If a type 2 were to
have beta cell burnout to the point that they could no longer produce enough
insulin to even meet basal needs and the person would go into ketoacidosis
without injections would he still be considered type 2?

David Dougherty



-----Original Message-----
From: email @ redacted [mailto:email @ redacted]On Behalf
Of email @ redacted
Sent: Saturday, October 23, 1999 10:30 PM
To: email @ redacted
Subject: [IP] RE:Type 2


<<If these measures do not solve the
problem then the person becomes insulin dependent and must obtain
insulin by other means (shots, csii, inhaler, etc...).>>

Clarification point:
The Type 2 individual becomes "insulin requiring". The type relates to
underlying cause of DM. Insulin dependent is reserved for Type 1. Many Type
2s continue to make some insulin as evidenced by the formation of C-peptide,
even though they may not be making enough to meet their metabolic needs. I
know this is a confusing point, especially for many physicians, and also, in
much of the contemporary literature.
There is also some evidence (not sure if it is all theory), that the drugs
that stimulate insulin secretion eventually exhaust the beta cells leading
the Type 2 individual to require insulin.
Barbara B.
(hoping I haven't added more confusion)

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