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[IP] Youngest Pumpers - 1986

Pediatrics 1986 Oct;78(4):625-30Related Articles 
Insulin pump therapy in the very low birth weight infant. 
Ostertag SG, Jovanovic L, Lewis B, Auld PA 
Ten critically ill, very low birth weight infants less than 30 weeks' 
gestation were treated with exogenous insulin administered through a 
continuous insulin infusion pump (Betatron II, Cardiac Pacemaker, Inc). 
Infants were hyperglycemic to dextrose infusions greater than 6 
mg/kg/min. The blood glucose concentration became normal in all infants 
within two to four hours, with varying requirements for continued 
insulin treatment. Tolerance to intravenous dextrose increased from a 
mean of 7.4 mg/kg/min to 11.2 mg/kg/min with glycosuria. Energy intake 
increased from 49.5 calories/kg/d prior to insulin pump therapy to 70.4 
calories/kg/d afterward (P less than .01) with weight gain changed from 
-23 g/d to +13 g/d (P less than .01). One unexpected observation was the 
apparent normalization of blood glucose homeostasis on higher dextrose 
doses among some infants after only one three- to six-hour treatment 
with insulin. The continuous insulin infusion pump is a flexible tool 
that allows insulin infusion rates to be changed as dictated by blood 
glucose values without altering other parenteral infusions. 
PMID: 3763272, UI: 8701607
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