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[IP] treatment for children under 3 - abstract from 1987

Arch Fr Pediatr 1987 Nov;44(9):759-64Related Articles 
[Treatment of diabetes in children under 3 years of age. Indications, 
methods and results]. 
[Article in French]
Boselli E, Bougneres PF, Couprie C, Chaussain JL 
Travail du Service d'Endocrinologie Pediatrique, Hopital 
Saint-Vincent-de-Paul, Paris.
Before modern methods of diabetes management were available, the 
achievement of strict glycemic control was considered almost impossible 
in most children with early onset of the disease. The present results 
obtained over 2 years in 31 children aged 21 +/- 2 (SEM) months at the 
onset of the disease indicate the efficiency of intensive conventional 
therapy in 21 of them: glycosylated hemoglobin averaged 7.0 +/- 0.3% (N 
= 4.7 +/- 0.7%) during the observed 26 +/- 7 months, with only 0.02 +/- 
0.01 hypoglycemic attack per patient-month and no diabetic ketoacidosis. 
In the remaining 10 children, who resisted intensive conventional 
therapy, we used insulin pumps to improve blood glucose control, with 
the following results over 21 +/- 4 months: Glycosylated hemoglobin 
decreased from 9.3 +/- 0.3% (before pump) to 8.0 +/- 0.4% (p less than 
0.05). The frequency of hypoglycemia decreased dramatically from 1.7 +/- 
0.7 to 0.03 +/- 0.01 episode per patient-month. The frequency of 
ketonuria and ketoacidosis was unchanged. We concluded that 
intensification of therapy through conventional means, or pump treatment 
if necessary, allows a long term efficient control of blood glucose in 
preschool children. 
PMID: 3328574, UI: 88182649 
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