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RE: [IP] Lantus question

One of the advantages of Lantus is that it's not supposed to have much
variability of absorption timing.  Thus, it should last only about 24
hours in the body.  One of the reasons that I do not take it any longer,
in fact, is that it used to wear off at about 20-22 hours, leaving me
with a tremendous high during the last few hours of the period.  I don't
believe that it's recommended to take the dose twice daily either, for
this reason.  It is usually prescribed to be taken in the evening,
sometimes in the morning, but not both.  So, what's happening is that
your brother is getting an overlap of the dosage.  He probably needs
that much during the day, or is compensating for it with extra carb
intake, but at night while sleeping, he cannot do this, so he is in
effect getting too much insulin.  Of course, we all know the solution to
this is pump therapy.  In the absence of that, however, I have read
recently that people were using the Lantus for their basic basal
insulin, then supplementing it with NPH, if necessary to cover any dawn
phenomenon, and Humalog or Novolog as needed for food intake.

Antonio in Los Angeles
Dx Type 1 1993 @ Age 27
Paradigm 512

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Sent: Thursday, November 13, 2003 2:21 PM
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Subject: [IP] Lantus question

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I have a question concerning Lantus.  My brother is currently using it
with Humalog.  It seems he is going low, around 40, in the early morning

 hours. He eats his glucose tabs and is still only around 70 when he
gets up at
am.  His doctor has told him to play with his numbers on both his
morning and 
evening Lantus as the doctor is not sure which could be causing the lows
 Lantus can stay in the system from 24 to 36 hours. That seems like a
to me.
Has anyone else had this problem?  And if so, which dose did you end up 
My brother has been a diabetic for 20 years, me for 40.  (He always
wanted to 
be like his big sis!).

Thanks in advance for any insight on this.  By the time I talk to him he
already have solved it but thought I would ask the "pros" anyway.  LOL

Debbie dx 3/63
pumping 3/00
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