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[IP] JAMA Article: Irregular cycles and type 2
The current issue of JAMA has an article indicating a significant
association between irregular or long menstrual cycles and type 2 DM risk.
I've copied the abstract below.
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The opinions expressed are mine and may not represent those of my wife who
runs our house and makes more important decisions than I do.
--- Begin Abstract ---
Long or Highly Irregular Menstrual Cycles as a Marker for Risk of Type 2
Caren G. Solomon, MD; Frank B. Hu, MD; Andrea Dunaif, MD; Janet
Rich-Edwards, DSci; Walter C. Willett, MD; David J. Hunter, MD; Graham A.
Colditz, MD; Frank E. Speizer, MD; JoAnn E. Manson, MD
Although oligomenorrhea has been associated cross-sectionally with insulin
resistance and glucose intolerance, it is not known whether oligomenorrhea
is a marker for increased future risk of type 2 diabetes mellitus (DM).
To prospectively assess risk of type 2 DM in women with a history of long or
highly irregular menstrual cycles.
Design and Setting
The Nurses' Health Study II, a prospective observational cohort study.
Participants A total of 101 073 women who had no prior history of DM and who
reported their usual menstrual cycle pattern at age 18 to 22 years on the
baseline (1989) questionnaire.
Main Outcome Measure Incident reports of DM, with follow-up through 1997,
compared among women categorized by menstrual cycle length (5 categories).
During 564 333 person-years of follow-up, there were 507 cases of type 2 DM.
Compared with women with a usual cycle length of 26 to 31 days (referent
category) at age 18 to 22 years, the relative risk (RR) of type 2 DM among
women with a menstrual cycle length that was 40 days or more or was too
irregular to estimate was 2.08 (95% confidence interval [CI], 1.62-2.66),
adjusting for body mass index at age 18 years and several other potential
confounding variables. The RR of type 2 DM associated with long or highly
irregular menstrual cycles was greater in obese women, but was also
increased in nonobese women (at body mass indexes at age 18 years of <25,
25-29, and 30 kg/m2, RRs were 1.67 [95% CI, 1.14-2.45], 1.74 [95% CI,
1.07-2.82], and 3.86 [95% CI, 2.33-6.38], respectively).
Women with long or highly irregular menstrual cycles have a significantly
increased risk for developing type 2 DM that is not completely explained by
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