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[IP] RE: insulin-pumpers-digest V4 #661

Diabetes In Control Newsletter - http://www.diabetesincontrol.com


          The Newsletter for Professionals in diabetes care

          November 28, 2000 Issue 28

Item #3

Scientists Eliminate Juvenile Diabetes

Just rodents so far, but maybe very soon for us

Scientists eliminate juvenile diabetes by using gene therapy to turn
rodent livers into insulin factories that regulate blood sugar at
near-normal levels for months.

Researchers who did not participate in the Korean-Canadian study said
while the results were a good start, it remains unclear whether they can
be applied to human diabetics.

``It's fair to say that this is the most efficient insulin gene therapy
that's been reported thus far. It's a nice first step, but there are a
number of things that need to be worked out,'' said Dr. Robert Sherwin,
president of the American Diabetes Association.

Although insulin activity in the treated rats and mice was only 20 percent
to 40 percent that of normal rodents, it was enough to regulate blood

The study, spearheaded by Hyun Chul Lee of the Yonsei University Medical
School in Seoul, South Korea, and three colleagues, appears in last
Thursday's issue of the journal Nature. For more on this story:

Item #4

To View the stamp: www.diabetesincontrol.com/issue28 and check out item #4

There will be a new postage stamp, designed by the U.S. Postal Service,
that will be available in March, 2001. The commemorative stamp was
unveiled at the Carousel of Hope Ball in Southern California.

With this stamp, the Postal Service continues a tradition of raising
public awareness of health and social issues. Some 16 million people in
the U.S. have diabetes and about one-third of them are unaware that they
have this chronic disease.

The stamp was proposed by the Juvenile Diabetes Foundation International
and is supported by the American Diabetes Association and the National
Institute of Diabetes and Digestive and Kidney Diseases at the National
Institutes of Health. The artwork includes two elements associated with
diabetes testing and research: a microscope and a test tube containing
blood. Courtesy of the U.S. Postal Service

Item #5 A person dies every 3 minutes from diabetes and 81% of the public,
have a Clue - Survey Shows Huge Gap in Public's Knowledge of the Disease

81 percent of Americans wrongly think taking insulin for Type 1 diabetes
delays and prevents the development of complications, which can include
kidney failure, blindness, limb amputation and nerve damage. There is a
large gap between what most of the general public knows about diabetes and
the actual facts about the disease. Even the most basic information eludes
many people while others underestimate the serious nature of diabetes, a
devastating disease that kills one American every three minutes.

These are general findings illustrated in the results of a survey
commissioned this year by the Juvenile Diabetes Research Foundation
International (JDRF). The survey, conducted by Penn, Schoen & Berland
Associates, Inc. of Washington, DC, posed ten key questions about diabetes
and its complications to a nationally representative field of respondents
in the United States, Canada, Australia and the United Kingdom. Its is
being released to coincide with National Diabetes Awareness Month --

According to the JDRF survey, 81 percent of Americans wrongly think taking
insulin for Type 1 diabetes delays and prevents the development of
complications, which can include kidney failure, blindness, limb
amputation and nerve damage. The United States is not alone in this
particular misconception. People in Canada (81 percent), Australia (86
percent) and the United Kingdom (76 percent) think the same.

At least half of the people in each of the four countries are not aware of
the difference between Type 1 and Type 2 diabetes nor can they identify
kidney disease, blindness or amputations as complications of diabetes.
Further, they do not know that diabetes is the single most costly disease
in terms of health care. For more on this story go to

Item #7

Drug Interactions with ACE Inhibitors

The field of interactions of natural medicines with allopathic medicines
and foods is growing at quantum speed because of a number of reasons.
First , more people are taking natural medicines today then ever before in
modern history, partly because of the increased quantity and accessibility
of both natural medicines and information about them. At the same time,
people are currently taking more conventional drugs than in the past.
Moreover, many people use both allopathic and alternative remedies at the
same time. As a result, there is a greater potential than has ever
existed for these two types of medicines  each having the ability to
alter the bodys biochemistry and functioning  to interact with each

Because the field of tracking and recording substance interactions is
continually expending, it is impossible to capture all of the potential
interactions of any kind at any given time. As the information becomes
available, we will share that information with you.

Following are some examples of notable interactions between conventional
and natural medicines. Interactions of foods and medicines are also
discussed. Because many people with diabetes are taking Ace Inhibitors,
we will go over some of the newer information regarding some of their
interactions. For the complete article:

Item #8

Protein under Development Restores Complete Nerve Function in
Pre-Clinical Models of Diabetic Neuropathy

Findings presented last week at the Fifth Annual Diabetic Neuropathy
Satellite Meeting of the Society for Diabetic Neuropathy showed that
treatment with the Sonic Hedgehog protein, under development by Curis,
Inc., restored nerve function to normal in pre-clinical models of diabetic

Data from a study conducted by Dr. David Tomlinson of the University of
Manchester showed complete restoration of both sensory and motor nerve
function in pre-clinical models after that function was impaired. Five
weeks after treatment on these models was begun, nerve conduction velocity
measurements showed that sensory and motor function returned to
pre-diabetic levels.

"The repair and restoration of normal function in nerves that have been
compromised by diabetes, as shown in this study, represents a key
objective of the company's efforts in developmental biology, and we are
moving forward aggressively to move such a therapy into human clinical
testing." For complete article:
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