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Re [IP] Re: Pork Insulin In The Pump????
Buffering means different things to different people. In the simplest
Chemistry 101 sense it refers to something added to water to keep the pH
(acidity) constant. But in a broader sense it refers to any additive that
"stabilizes" solutions. Buffering in insulin bottles is both used to
maintain pH and to make the liquid compatible with the body fluid between
cells (interstitial fluid). The chemicals used for buffering might cause
some irritation after injected, but this is pretty rare. These reaction
problems are more often caused by reaction to the impurities (undesired
proteins) associated with imperfect purification of animal insulins.
Injected insulin is also in what is called a bound form (several molecules
tied together), and needs to be broken up into individual molecules before
it can function as insulin in the blood. This is the reason why some
insulins are long acting and others are fast acting. It relates only to
how quickly the insulin molecules can be separated after injection.
Humalog works faster than other insulins because the molecules are
separated more quickly--once in the blood all insulins work at the same
rate. In some individuals the buffering chemicals might also affect the
rate at which the insulin molecules are separated and absorbed into the
blood, but not much is known about this. It is probably not a big factor.
Buffers used by different manufacturers may be incompatible, but since they
usually don't test all the ways which people (i.e., us) can mix things,
they just categorically recommend that we not mix. But since we do what we
want anyway, if you think something might work for you, just try it.
You'll know pretty quickly if the buffers are incompatible. My mother used
to say , "If you want something done well, do it yourself." But for us
pumping diabetics, the motto needs to be changed to, "If you want something
done at all, do it yourself."
From: "Michael" <email @ redacted>
> What exactly is the function of the 'buffering compound'?
There is a good description somewhere on the internet. The buffering
compound is the liquid solution you see in the vial that actually
carries the insulin molecule. There are several in use, and if the
'wrong' ones are mixed you get a gluey mess that is not useable as a
medication. There are some warnings on the drug company websites in
the 'patient' guides that mention this. There are some additional
things the buffer solution does with respect to moving the insulin
molecule through the cell wall, but I have not exceed the extent of
my knowledge. Perhaps one of the more knowledgable list members can
fill in the details.>>>>>>>>>>>
Insulin-Pumpers website http://www.insulin-pumpers.org/