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[IP] Implantable pump (abstract)

Diabetes Metab 2002 Apr;28(2):133-7 <A HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Display&dopt=pubmed_pubmed&from_uid=11976565">Related Articles, </A><A HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11976565&dopt=Books"></A>Books, <A HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11976565&dopt=ExternalLink">LinkOut</A>    

Comparison of blood glucose stability and HBA1C between implantable insulin 
pumps using U400 HOE 21Ph insulin and external pumps using lispro in type 1 
diabetic patients: a pilot study.

Catargi B, Meyer L, Melki V, Renard E, Jeandidier N; For the EVADIAC Study 

Service d'Endocrinologie, Hopital Haut-Leveque, avenue de Magellan, 33604 

BACKGROUND: To assess the efficacy on blood glucose control of continuous 
peritoneal insulin infusion from implantable pump (CPII) compared with 
continuous subcutaneous infusion using insulin lispro (CSII-IL) in type 1 
diabetic patients.METHODS: Fourteen type 1 diabetic patients (5 males and 9 
women, age 50.6 +/- 12.8, diabetes duration 28.0 +/- 13.4 years) were treated 
with CSII-IL and CPII. Capillary blood glucose (BG) was monitored and 
recorded at least 4 times per day during 2 study periods of 45 days: using 
CSII-IL (period A), and from 45th to 90th day after implantation (period B). 
HbA(1C) was measured at the end of each period.RESULTS: Both daily BG levels 
(145 +/- 18 vs 153 +/- 17 mg/dl, p<0.01) and preprandial BG levels (139 +/- 
20 vs 147 +/- 22 mg/dl, p<0.05) were lower in period B. Although postprandial 
BG values tended to be lower in period B, this reduction did not reach 
statistical significance (149 +/- 20 vs 157 +/- 16 mg/dl, p=0.07). Meanwhile, 
SD of all BG values was lower with CPII (69 +/- 11 vs 79 +/- 17 mg/dl, p<
0.01) and HbA(1c) levels were lower at the end of period B (7.3 +/- 0.9 vs 
7.8 +/- 0.9%, p=0.04). Low blood glucose index was comparable during both 
periods (2.8 +/- 1.6 vs 3.1 +/- 1.5, p=0.4).CONCLUSION: CPII may provide a 
better BG control and stability than CSII-IL. However, a long-term randomized 
prospective study is needed to confirm these improvements.

PMID: 11976565 [PubMed - in process]     <A HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11976565&dopt=Abstract">Entrez-PubMed</A> 
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