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[IP] Prednisone and its effects



COPING WITH PREDNISONE
Eugenia Zuckerman and Julie B. Ingelfinger, MD
Saint Martin's Press

it has great practical advice on dealing with all of the wonderful side
effects.

ADVERSE REACTIONS: Summary box listed on pp 64-65

ENDOCRINE (Glandular) AND METABOLIC CHANGES
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Changes in body contour, with fat deposits on trunk, on the cheeks (moon
face), over the back of the neck, around the neck, yet sparing of the
arms and legs.
High blood sugar (steroid diabetes)
Increase in blood fat (hyperlipoproteinemia)
Negative balance of calcium, nitrogen, potassium (catabolic state)
Salt retention
Suppression of the adrenal glands
Menstrual abnormalities
Impotence
Suppression of the growth of children

SKIN AND HAIR CHANGES
~~~~~~~~~~~~~~~~~~~~~
Facial reddness (plethora)
Thin, fragile skin
Bruising
Stretch Marks
Acne
Slow wound healing
Thinning of the scalp hair
Increased body hair

EYE CHANGES
~~~~~~~~~~~
Cataracts (posterior subcapsular cataracts
Increased intraocular pressure (glaucoma)
Eyeball prominence (exophtalmos)

MUSCLE AND BONE (Musculoskeletal) CHANGES
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Weak muscles (myopathy)
Osteoporosis
Osteonecrosis

GASTROINTESTINAL (GI) SIDE EFFECTS
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Gastritis
Peptic Ulcer
Thrush
Pancreatitis

CARDIOVASCULAR CHANGES
~~~~~~~~~~~~~~~~~~~~~~
Hypertension
Congestive Heart Failure (only in predispositioned patients)

MOOD/NEUROPSYCHIATRIC CHANGES
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Alterations in mood
Psychosis
Convulsions
Pseudotumor cerebri (benign intercranial hypertension)

INFECTIOUS/IMMUNE CHANGES
~~~~~~~~~~~~~~~~~~~~~~~~~~
Increased susceptibility to infections
Suppression of immune responses (decreased inflamatory response;
suppression of delayed hypersensitivity)
Changes in white blood cell population, with increase in some cells
(meutrophilis) and decrease in others (lymphocytes and monocytes)
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