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[IP] Inhaled insulin - ADA research report
- Subject: [IP] Inhaled insulin - ADA research report
- From: "JHughey" <email @ redacted>
- Date: Fri, 5 May 2000 16:23:55 -0500
I got a DM newsletter that included an article from Research Report, ADA.
Thought I'd share the info:
NEW ADVANCES IN THE FIGHT AGAINST DIABETES
Reducing or eliminating the need for multiple daily insulin shots would be
welcome news for millions of Americans with diabetes. Unfortunately, insulin
cannot normally be taken by mouth because the pills are rendered useless as
a hormone when they are digested in the stomach. Sniffing insulin through
the nose has its own set of dosing problems, including local irritation and
erratic absorption - especially if the individual has a cold.
Now, thanks to research supported by the American Diabetes Association, the
first major clinical trials of a new inhaled form of insulin to treat people
with the two most common types of diabetes have been successfully completed.
The results are an important advance in the search to avoid shots.
The new portable aerosol delivery system, about the size of a flashlight, is
similar to an asthma inhaler. It delivers a dose of insulin in dry powder
through the mouth, directly into the lungs, where it easily enters the blood
circulation as a rapid-acting insulin. Plus, delivering the insulin directly
into the lungs appears to be much more comfortable than sending it through
the nasal passages. The device was created by Inhaled Therapeutics Systems,
Inc., and is being developed for use in diabetes in collaboration with
One trial focused on people with Type 1 diabetes, who require daily insulin
injections to survive. The second trial focused on people with Type 2
diabetes, which can often initially be treated with diet or oral drugs. But
as the disease progresses, insulin injections may become necessary. With
both groups, the inhaled insulin performed as well as injected insulin,
according to researchers.
Overall, patients were delighted with the inhaled system. Phase 3 trials
began in November, 1998. At this stage of drug research, it usually takes
another three to five years before FDA approval can be expected.
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