[Previous Months][Date Index][Thread Index][Join - Register][Login]
[Message Prev][Message Next][Thread Prev][Thread Next]
[IP] hey lookie here
- Subject: [IP] hey lookie here
- From: email @ redacted
- Date: Fri, 14 May 1999 00:16:32 EDT
Hi kids...this is sara checking in from vacation...dont know if y'all saw
this today but thought it would be of interest!!!
PS - I met Jessica and Anita in Houston - COOL!!!!! and gonna meet Sandra in
Lake Charles...I love IP
Gene Found That May Cause Diabetes
.c The Associated Press
By PAUL RECER
WASHINGTON (AP) -- Researchers have taken a critical step toward a vaccine to
prevent childhood diabetes by isolating in mice a gene that causes the body
to attack and kill tissue that produces insulin.
(CHILDHOOD???why not call it TYPE I??? that IS the correct term for it, is
Using a strain of rodent, called the nonobese diabetic mouse, that always
gets diabetes, a team led by Dr. Ji-Won Yoon showed that the presence of the
gene GAD is what causes the body's immune system to kill the
insulin-producing cells. Yoon, of the University of Calgary in Alberta,
Canada, is lead author of a study appearing Friday in the journal Science.
``We found that if we suppress GAD expression in the pancreatic cells, then
we can prevent diabetes,'' said Yoon. ``It is that simple.''
(YAH RIGHT...THEN WHY DON'T THEY JUST DO IT!!!!!)]
In the mouse, when the GAD gene is active, it expresses, or causes the cell
to make, a protein called glutamic acid decarboxylase. When this GAD protein
is circulating in the body, the immune system detects it and attacks as if it
were a foreign substance. Killer T-cells from the immune system also attack
the beta cells that have the GAD gene. This attack kills the beta cells,
which means the body no longer has the insulin needed to process glucose, or
sugar, in the blood. The result is Type I diabetes. (THANK YOU...)
Dr. Robert Goldstein, medical director of the Juvenile Diabetes Foundation,
said Yoon's discovery ``is very important step'' toward, perhaps, someday
developing a diabetes vaccine.
``This approach has the promise of modulating the autoimmune response and
going toward prevention,'' said Goldstein. He cautioned, however, that the
finding is ``only one brick in the house'' and that scientists will need to
answer many basic questions before a vaccine can be developed.
Type I diabetes frequently is diagnosed in childhood, forcing patients to
spend their lives taking up to four insulin shots a day and to monitor
carefully their blood sugar levels. About 29,000 new cases of Type I
diabetes are diagnosed annually in the United States, mostly among children
and young adults. The Juvenile Diabetes Foundation estimates that about one
million Americans now are being treated for Type I diabetes.
Another form of the disease, called Type II diabetes, most commonly occurs in
people over 40. In this disease, the body may still make insulin, but cells
have lost their sensitivity to the hormone. Type II diabetes commonly is
treated successfully with pills, diet and life style changes.
(Well this is good - at least they are differentiating between the two -
never seen an article like this that calls out the two "species")
When not controlled, either type of diabetes can cause kidney failure,
blindness, limb amputation, heart disease and death. It is estimated that
diabetes claims the lives of about 190,000 Americans annually.
Yoon said his study suggests that it may be possible to prevent Type I
diabetes with a vaccine that would desensitize the immune system to the
presence of the GAD gene. He said such a vaccine would, in effect, educate
the immune system to not attack pancreatic cells that have the GAD gene.
``If you inject GAD then the T-cell will learn to tolerate GAD and will not
attack the beta cells (which make insulin),'' said Yoon. ``The concept is
that you inject GAD into young children then they would not get diabetes.
That is prevention.''
Yoon said that it will take 10 to 15 years to develop such a vaccine because
researchers would have to prove that manipulating the GAD gene would not
cause dangerous side effects. He said the gene has no known function in the
pancreas, but it is present in the brain..
Insulin Pumpers website http://www.insulin-pumpers.org/
for mail subscription assistance, contact: HELP@insulin-pumpers.org