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[IP] Safety and Effectiveness of Insulin Pump Therapy in Children and Adolescents Wit



  <A
HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12663587&dopt=Abstract">Entrez-PubMed</A>

Diabetes Care 2003 Apr;26(4):1142-1146  >Links</A>   

Safety and Effectiveness of Insulin Pump Therapy in Children and Adolescents 
With Type 1 Diabetes.

Plotnick LP, Clark LM, Brancati FL, Erlinger T.

Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland. 
Department of Medicine, Johns Hopkins University, Baltimore, Maryland. 
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 
Baltimore, Maryland. Welch Center for Prevention, Epidemiology and Clinical 
Research, Baltimore, Maryland.

OBJECTIVE-To evaluate the safety and effectiveness of insulin pump therapy in 
children and adolescents with type 1 diabetes. RESEARCH DESIGN AND 
METHODS-All 95 patients who began insulin pump therapy at Johns Hopkins 
Hospital between January 1990 and December 2000 were included in the study. 
The mean age was 12.0 years (range 4-18), and 29% of the patients were <10 
years old. Data were obtained by chart review beginning 6-12 months before 
pump start. The median duration of follow-up was 28 months. RESULTS:-There 
was a small but significant decrease in HbA(1c) at 3-6 months after pump 
start (7.7 vs. 7.5%; P = 0.03). HbA(1c) levels then gradually increased and 
remained elevated after 1 year of follow-up; however, this association was 
confounded by age and diabetes duration, both of which were associated with 
higher HbA(1c) levels. After adjusting for duration and age, mean HbA(1c) 
after pump start was significantly lower than before pump start (7.7 vs. 
8.1%; P < 0.001). The number of medical complications (diabetic ketoacidosis, 
emergency department visits) was similar before and after pump start. There 
were fewer hypoglycemic events after pump start (12 vs. 17, rate ratio 0.46, 
95% CI 0.21-1.01). CONCLUSIONS:-This study suggests that pump therapy is safe 
and effective in selected children and adolescents with type 1 diabetes.

PMID: 12663587 [PubMed - as supplied by publisher]  
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