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[IP] Metformin to prevent miscarriage

A few months ago my best friend( pregnant) called
and told me she had polycystic ovaries and her Doctor put her on Glucophage, a
medication usually used for Type 2 Diabetes, to prevent a miscarriage. I had
not heard anything about this until this morning I came across this article.
Thought it might help someone somewhere \  Pass it along


Diabetes drug may prevent some miscarriages
The diabetes drug metformin dramatically reduces the risk of miscarriage in
women affected with the most common form of infertility, according to research
published in the February issue of The Journal of Clinical Endocrinology &

Between 5 and 10 percent of American women have polycystic ovary syndrome
(PCOS), a condition in which the ovaries fill with small cysts and levels of
the male hormone testosterone rise abnormally high. Women with PCOS are more
likely to be obese and to have high blood pressure and diabetes. The imbalance
of male hormones can lead to irregular periods and disrupt ovulation, making
conception difficult if not impossible. Women who do get pregnant run a 30 to
50 percent risk of having a miscarriage, a three times greater risk than that
of healthy women.

Researchers at the Hospital de Clinicas Caracas in Venezuela have discovered
that the drug metformin, commonly used to treat diabetes, significantly
reduces the miscarriage risk for women with PCOS. In a study of 96 pregnant
women with PCOS, only 8.8 percent of women who took metformin throughout their
pregnancy miscarried, compared with 41.9 percent in the group that did not
receive the drug.

The authors theorize that the high miscarriage rate is related to insulin
resistance in women with PCOS. Metformin works by increasing insulin
sensitivity, which lowers testosterone levels, improves blood flow to the
uterus, and leads to the expression of several proteins necessary for
implantation, says senior author John Nestler, chairman of endocrinology at
the Medical College of Virginia.

The U.S. Food and Drug Administration has approved metformin for the treatment
of diabetes, but doctors are increasingly prescribing it as a fertility drug
and to prevent miscarriage in women with PCOS. Nestler says studies have shown
the drug to be safe when taken throughout pregnancy.

What you can do
Talk to a fertility specialist to find out whether this drug is right for you.
Metformin has been shown to prevent miscarriage only in women with PCOS and
may not be the best treatment for your condition. Although miscarriage is
relatively common (at least one in ten known pregnancies ends in miscarriage,
and more women may miscarry before they even know they're pregnant), the cause
is often unknown.

. Read more about polycystic ovary syndrome.

. Read more about miscarriage and how to cope.

- By Stephanie Watson

>From BabyCenter

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