# [IP] Novolog and Humalog

```Do you really want to know? The data in the figure two curve of the Lilly
Humalog sheet can be converted to an equation that produces that curve when
graphed. With that equation the data can be calculated for any time or time
increments. A table of such values at 3 minute intervals was generated. Then,
because the Animus delivers a dollop each 3 minutes and because the response
to each such is simply additive to whatever is in the blood already, many
columns of repeated numbers were placed in the spread sheet. Each column was
time offset from the one to its left by 3 minutes. That gave a table of what
each time displaced dollop was doing. The leftmost column of the spread sheet
page with that stuff on it is the simple sum of what is in that row, row by
row. That is, the net insulin is the sum of the individual mini doses each
playing through at 3 minute separations. That is how it was done and that is
what you will see in the spread sheet. However, you do not have an Animus and
I need to know how the Minimed puts in the basal. How much and how often?
That and the drop test will allow me to generate a similar but customized
basal transient curve for you. The drop test first derivative (the slope)
produces the counterpart to fig two. From there the steps are similar but
differ in the magnitudes and probably the time steps because of minimed vs
animus basal delivery timing. Your friend is overlooking the fact that the
diffusion data is implicit in the Humalog data sheet curve. That is a real
response in typical of a group of people. Add to that the knowledge that
double the dose produces double the result when insulin is injected (that is,
the response to dose is  linear) and the application of linear superposition
takes care of the calculation of how mini doses staged 3 minutes apart
combine. Is it good to three decimal places? No. Does it need to be? No. We
are only attempting to relate the basal responses to the basal rate time
block that is responsible and for that super precision is not needed. As the
basal response is monitored, that same dose dynamic gives at least a notion
of what insulin intensity that was passed during the transient accounted for
the momentarily flat baseline. That facilitates the estimate of what the next
attempt at basal rate should be as one works through the proportional
scaling. There is no fundamental dependence on highly precise numbers in the
above basal rate adjustment  process so the fact that some reasonable
simplifying assumptions about the mechanism of combination of mini doses was
made should not bother anyone.  Regarding potency, the assumption is that the
fig 2 novolog curve and the fig 2 humalog curve are taken under similar
conditions of injection site. They are the average responses of a group of
people so individual variation is accounted for. The respective AUC of the
two gives the single bolus potency comparison. When we did that with R and H
I calculated .9075 and we later measured .91. I have not done that
calculation for Novolog vs H because I do not see us using both. I did do it
for the basal transient curves (which relate through a different ratio than a
single bolus ratio) because I suspected you would attempt to do a pump switch
to Novolog and I wanted to forestall a hypo created in ignorance of the
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