[IP] Insulin potency vs temperature
I've collected a number of sources that show that insulin has an
extremely long shelf life. I thought it would be useful to post this
information to the group.
Diagnosis and Management of Diabetes Mellitus, 2nd ed.
Olson, Charles O., Raven Press (New York, 1988), page 64
NPH, all Lentes, and PZI, are stable for 24 months at room
temperature. All insulins are stable for 36 months under
Galenics of Insulin
Brange, Jens, Springer-Verlag (New York, 1990), Table 16, page 59
The time to 2%/5% potency reduction at various temperatures:
39 deg F 59 deg F 77 deg F 104 deg F
Actrapid 36/92 yrs 5/13 yrs 12/31 months 5/14 weeks
Ultralente 19/48 yrs 2/5 yrs 4/10 months 1/3 weeks
Stability and sterility of biosynthetic human insulin stored in
plastic insulin syringes for 28 days
Tarr BD, Campbell RK, Workman TM
Am J Hosp Pharm 1991 Dec 48:2631-4
The potency of insulin in each of the biosynthetic human insulin
products [regular, isophane, combination, and extemporaneously
prepared combination] did not change significantly during the 28-day
study... at both temperature settings [39 deg F & 80 deg F].
Stability of U-10 and U-50 dilutions of insulin lispro
Stickelmeyer MP, Graf CJ, Frank BH, Ballard RL, Storms SM
Diabetes Technol Ther 2000 Spring 2:61-6
Insulin lispro when diluted with the appropriate diluent
demonstrates acceptable stability when stored at [41 deg F] and [86
deg F] for a period of 32 days.
If anyone has additional sources to add to this list or *contradictory
studies* (no case histories, please), let me know.
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