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[IP] Don't disconnect just yet...

>From Yahoo Health Headlines June 15, 2001. Wouldn't it be terrific? If you 
don't like porkchops, do your best to develop a taste for 'em. Looks like 
you've still got two years in which to do it.
 Gil Linkswiler 46 years T1, MM508 5/01
Friday June 15 8:44 AM ET 
Transplanted Pig Cells Help Control Diabetes
By Patricia Reaney

LONDON (Reuters) - A baboon injected with pancreatic pig cells could be the 
beginning of the end of daily insulin injections for millions suffering from 
diabetes, scientists said on Friday.

Since researchers at Duke University in North Carolina injected a diabetic 
baboon called Babs-92 with specially encapsulated insulin-producing cells 
from pigs nine months ago the primate has not required any insulin to control 
the disorder.

If Babs continues to do well Dr. Emmanuel Opara and a team of scientists at 
Duke believe human trials of the technique could begin within two years.

``Once we can replicate the results in clinical trials, I think it could be 
the end of daily injections,'' Opara, an associate research professor of 
experimental surgery and cell biology, said in a telephone interview.

Insulin injections are not a cure for diabetes. They help diabetics control 
their blood sugar levels but the injections do not reduce their risk of 
developing other serious complications such as kidney failure, heart disease 
and strokes.

Opara believes the pig cell transplant could be a potential cure for many 
sufferers of the disease that afflicts an estimated 135 million worldwide, 
because in addition to providing insulin patients would also receive 
C-peptide, a precursor form of insulin.

``We know it is very, very helpful in preventing the complications of 
diabetes,'' Opara, who presented his research at an international transplant 
meeting in Innsbruck, Austria, explained.


The cells can be injected into the abdomen of humans using minimally invasive 
surgical techniques, Opara said.

``We do not know how many patients with diabetes would need this therapy, but 
the baboon data to date is very encouraging,'' he added.

Insulin is a hormone produced by cells in the pancreas which controls blood 
sugar levels and metabolism. People suffering from Type I diabetes have cells 
that do not work properly and they need daily insulin injections.

Opara and his team coated the pig cells with a complex carbohydrate known as 
alginate, which provides a protective sphere, and injected them into the 
Babs-92's abdominal cavity. Five more baboons have also received pig cells.

The coating acts as a one-way door that allows the insulin out but the 
baboon's antibodies and immune cells that attack the transplant cannot get 
in, which eliminates the need for anti-rejection drugs.

Opara said he was not sure how many cells will be needed for a human 
transplant but be believes the more than 90 million pigs that are used for 
food production in the United States each year should assure a steady supply.

The technique, if proven effective and safe, could help Type 1 diabetes 
sufferers and Type 2, or adult onset, diabetics who need injections. 
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