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[IP] Lente-Ultra Lente

Thev primary reason for the caution about mixing Lente or Ultra Lente was
that the protein that they added to Lente or Ultra Lente was protamine, The
same that they add to NPH (Neutral Protamine Hagedorn) insulin, except NPH
has only enough protamine added and no excess (Hence Neutral) left to react
with other insulin that you add, so the time spectrum is not disturbed (so
to speak) Adding Insulin to Lente or semilente changes its onset of action
and brings out the caution that Lilly adds to every product circular "do
not mix insulins or change the type unless specifically told to do so" That
phrase is probably required by Federal law. Actually even regular and NPH
will react as evidenced by the clouding of the regular when you add the NPH
to it. Lots of us got hives and itching from the protamine and lumps from
the c-peptide in the animal insulins they used to sell. Glad all that is
becoming a distant memory thanks to the pump. NPH was supposed to peak
about 4 to 6 hours after injection.Lente just really didn't peak and
continued to act for hours as did Protamine Zinc and Insulin which lasted
about 14 hours or more. great for sleeping in on Sunday morning but not
great for getting sugars down.
A Bender, M. D.
email @ redacted
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