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Re: [IP] Velosulin Humulog mixture
> About 2 summers ago I sent an experimental study to this
> list (which is in the archives) where I carfefully compared the
> duration of sites over 3 months with either pure H or a 5:1 H/V mix.
> There was no difference in the length of time a site would last with
> me. To see if the mix ratio were a factor, last summer I tried
> using pure V for a month, but my sites still only go about 4 days.
> Sometimes they seem to last longer ( record is 8 with H), but I more
>or less routinely change them at 4 days.
> V does
> something to make sites longer. If you are one then you should
> surely use the mix. Its ymmv in this business as we all know, and
> the placebo effect has very well documented medical effects. If you
> think it works then go for it! -wayne
This is a pretty accurate statement and a good example of the
knowledge you need to gain before trying a mix. Only a small number
of people have irritation from Humalog (or any other insulin for that
matter) this is almost always due to particular components of the
buffer compound and not the insulin itself. If you suspect that you
have a problem with site degradation DUE TO HUMALOG sensitivity, you
can really only verify it by not using Humalog as Wayne did, for a
at least couple of weeks. If there is no obvious difference in site
longetivity, then mixing insulin will not help at all and will
probably just complicate your life. On the other hand, if you see a
marked difference in site longetivity, then you might benefit from
mixing. It is not good enough just to try a mix -- there has to be a
verifiable reason to do so. Wayne's results make it clear that for
some (probably most) people, site life is not affected by the insulin
My daughters experience was quite the opposite of Wayne's and
demonstrates why a control experiment is necessary. She switched to
Humalog right after it came out and her doc gave her a bottle to try.
The control results (as you all know) are much better with Humalog
because of the faster response time. However, Lily's sites would
routinely go bad after 36 to 48 hours. Her bg's would simply start
going up. A high bg bolus would bring them down, but they would
simply go back up again. Changing the site would eliminate the
problem for another 1 1/2 to 2 days and it would start again. She
switched back to Velosulin and the problem disappeared. She was again
able to change her sites twice a week, ever third and fourth day,
without any rise in bg's near the end of the change period. She
stayed on Velosulin for a month and we watched the situation very
closely because of the anamolus results with Humalog which had given
her site life of only 1 1/2 to 2 days for the month she used it. We
then tried the 5/1 mix and subsequently a 4/1 mix and found that both
would provide the same site life as the Velosulin trial. She did not
like the extend insulin activity with 4/1 and has stayed with 5/1
since then about 2 or 3 years now.
As they say, YMMV.
I reiterate, if you think you have a problem with Humalog, don't
waste your time mixing unless you can demonstrate that NOT using
humalog solves the problem. Lots of things can cause site problems,
Humalog sensitivity is pretty low on the totem pole.
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