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[IP] Who Funded This Study?

The abstracts from the scientific sessions in San Diego are now available on 
line at

Abstract #:
0050 Abstract Category:Clinical Diabetes, Therapeutics/New Technology 

Use of Insulin Pump Therapy At Night Only for Pre-Teen Children with 
Type 1 Diabetes 

Francine R Kaufman*, Mary J Halvorson*, Christina Kim, Childrens 
Hospital Los Angeles, Los Angeles, CA 

Although continuous subcutaneous insulin infusion via an insulin pump 
has gained wide-spread acceptance in adolescents & adults with type 1 
diabetes, it may have limited usefulness in pre-teen children because 
they may not be developmentally capable of managing the pump without 
parental supervision. As a result of this, we evaluated the efficacy of 
pump therapy (MiniMed 507C)only at night in 10 children, ages 7-10 
years. Children were randomly selected based on inclusion criteria; mean 
duration of diabetes was 3.4  1.6 years, mean HbA1C of 7.6  0.9% and 
patients took 0.9  0.3 units of insulin/kg/day. After 4 wks of 3 
insulin injections/d plus supplemental correction doses per standardized 
algorithm, a cross-over design with random assignment to either 3 
insulin injections/d or pump at night (pump used for dinner insulin & 
throughout the night with a.m. insulin injection of lispro and NPH; 
total daily dose distributed as 60%injectable & 40% pump) was 
implemented. Study time on pump and injections was 4 wks with a 2 wk 
stabilization period for pump initiation. Data collection included 
fructosamine levels & 5 BG levels/d to determine changes in diabetes 
control as outlined in Table 1. Scores of fear of hypoglycemia were pre 
27  15 and post 12  9 (p=0.02) & for adherence were pre 77  11 & post 
86  6 (p=0.04).These data suggest that the use of the insulin pump at 
night only in pre-teen children improves overall glycemia & BG levels at 
breakfast, bed & in the night without causing an increase in 
hypoglycemia. Insulin pump therapy at night only may be a viable option 
for pre-adolescents who need to improve glucose control but who are not 
yet ready to manage the pump during times when there is no parental 
Insulin Pumpers website http://www.insulin-pumpers.org/
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