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[IP] Metabolic Factors Associated with Benign Prostatic

I have a PDF File on the full text of the report if anybody wants it. It has
not been available on the internet.

mailto:email @ redacted

The James Buchanan Brady Urological Institute (J.K.P., H.B.C., A.W.P., P.L.,
E.A.P.), The Johns Hopkins Medical

Institutions, Baltimore, Maryland 21287; The National Institute of Aging,
Clinical Research Branch (B.G.W., E.J.M., L.F.),

Harbor Hospital, Baltimore, Maryland 21225; and The Department of
Epidemiology (E.A.P.), The Johns Hopkins

Bloomberg School of Public Health, Baltimore, Maryland 21205

Context: Benign prostatic hyperplasia poses a significant public

health problem, but its etiology remains unclear. Obesity and associated

abnormalities in glucose homeostasis may play a role in benign

prostatic hyperplasia development by influencing prostate growth.

Objective: The objective of this study was to determine whether

obesity, fasting plasma glucose concentration, and diabetes are associated

with radiologically determined prostate enlargement, an objective

measure of benign prostatic hyperplasia.

Design: This study was a cross-sectional analysis with robust variance

estimates to account for multiple measures over time in the same


Setting: This prospective cohort study was composed of community


Patients: Patients studied were 422 adult men enrolled in The Baltimore

Longitudinal Study of Aging.

Main Outcome Measurements: Total prostate volume as determined

by pelvic magnetic resonance imaging was measured.

Results: Among 422 participants, 91 (21.6%) had prostate enlargement

(defined as total prostate volume _ 40 cc) at first visit. Compared

with men of normal weight [body mass index (BMI)_25 kg/m2],

the age-adjusted odds ratio (OR) for prostate enlargement for overweight

men (BMI, 25-29.9 kg/m2) was 1.41 (95% CI, 0.84-2.37), for

obese men (BMI, 30-34 kg/m2) was 1.27 (95% CI, 0.68-2.39), and for

severely obese men (BMI _ 35 kg/m2) was 3.52 (95% CI, 1.45-8.56)

(P_0.01). Men with elevated fasting glucose (_110 mg/dl) were more

likely to have an enlarged prostate than men with normal fasting

glucose (_110 mg/dl) (OR, 2.98; 95% CI, 1.70-5.23), as were men with

a diagnosis of diabetes (OR, 2.25; 95% CI, 1.23-4.11).

Conclusions: Obesity, elevated fasting plasma glucose, and diabetes

are risk factors for benign prostatic

John S Wilkinson,
Rome, New York

John S Wilkinson,
Rome, New York
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