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[IP] Re: Re: Use of oral agents in teenagers

>>From: "margo2" <email @ redacted>
I suppose that depends on how one would define "true insulin resistance". To
me, there are different forms of insulin resistance, including that caused
by hormones, illness, medication,
stress, etc.<<


It doesn't depend on how you or I define "insulin resistance" but how 
it is scientifically defined.  It is a syndrome where your body 
manufactures too much insulin (Type 1's do not put out any insulin) 
because his/her cells cannot respond appropriately.  Here are a 
couple sources that explain it technically.  There are many, many 
more if you want to research it.

Most people who develop diabetes in later life can be controlled so 
that they are not at increased risk for the many complications of 
diabetes such as heart attacks, strokes, blindness, deafness,
amputations, kidney failure and burning foot syndrome. Late onset 
diabetes usually means that a person has too much insulin because his 
cells cannot respond to insulin. Too much insulin
constricts arteries to cause heart attacks, and stimulates your brain 
and liver to make you hungry and manufacture fat. The insulin 
resistance syndrome (IRS) puts you at very high risk for a heart
attack and is associated with storing fat in the belly, rather than 
the hips; having high blood triglyceride levels and low level of the 
good HDL cholesterol; high blood pressure and an increased
tendency to form clots.

Insulin stimulates glucose uptake into tissues, and its ability to do 
so varies greatly among individual persons. In insulin resistance, 
tissues have a diminished ability to respond to the action of 
insulin. To compensate for resistance, the pancreas secretes more 
insulin. Insulin-resistant persons therefore, have high plasma 
insulin levels. The syndrome can be defined as a cluster of 
abnormalities, including obesity, hypertension, dyslipidemia and type 
2 diabetes, that are associated with insulin resistance and 
compensatory hyperinsulinemia.

Cindy, mom to 16 y/o Noah, dx age 9, pumping since 6/99
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