[Previous Months][Date Index][Thread Index][Join - Register][Login]   Help@Insulin-Pumpers.org
  [Message Prev][Message Next][Thread Prev][Thread Next]   for subscribe/unsubscribe assistance
 
 

[IP] theophylline on glucose counterregulation ..& unawareness of hypoglycemia



 <A
HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&li
st_uids=12844138&dopt=Abstract">Entrez-PubMed</A>
Clin Pharmacol Ther. 2003 Jul;74(1):77-84.
 
Effect of 2 weeks of theophylline on glucose counterregulation in patients
with type 1 diabetes and unawareness of hypoglycemia.

De Galan BE, Tack CJ, Lenders JW, Lutterman JA, Smits P.

Background and objective A single dose of theophylline improves hypoglycemia
unawareness in type 1 diabetic patients. Prolonged theophylline use is,
however, associated with emergence of tolerance. This study investigated
whether
prolonged use of theophylline retains efficacy for counterregulatory defects
in
patients with type 1 diabetes and hypoglycemia unawareness. METHODS:
Experiments were performed with 12 subjects with type 1 diabetes and
hypoglycemia
unawareness. All subjects participated in a crossover study of 2 randomly
scheduled
15-day study periods during which 250 mg theophylline twice daily or matching
placebo was used. On the final day of each period, hyperinsulinemic (360 pmol.
m(-2). min(-1)) hypoglycemic (5.0, 3.5, 2.5 mmol. L(-1)) glucose clamps were
used to assess counterregulatory and cardiovascular responses. RESULTS: Under
normoglycemic conditions, there were no differences between theophylline and
placebo. Under hypoglycemic conditions, theophylline enhanced responses of
growth hormone, symptoms, heart rate, and pulse pressure (all P <.05), induced
sweating at higher plasma glucose levels (P =.039), and reduced exogenous
glucose
requirements (P =.018). Hypoglycemia-induced responses of epinephrine,
norepinephrine, and cortisol were not enhanced by theophylline. CONCLUSIONS:
Prolonged use of theophylline has a sustained effect on cardiovascular,
metabolic,
and symptom responses to hypoglycemia in patients with type 1 diabetes and
hypoglycemia unawareness. Whether these results translate into clinical
benefit
remains to be determined.

PMID: 12844138 [PubMed - in process]


 <A HREF="http://allergy.mcg.edu/advice/theoph.html">Update On
Theophylline</A>
----------------------------------------------------------
for HELP or to subscribe/unsubscribe, contact:
HELP@insulin-pumpers.org