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[IP] ADA: Noninvasive Blood Glucose Monitor Tested in Diabetics
Coming soon or just another pipe dream?
ADA: Unlike currently available blood glucose monitors, which require
finger prick or other invasive testing for calibration one or more times
daily, a new blood glucose monitor presented at the American Diabetes
Association 62nd Scientific Sessions in San Francisco, California, is
"The tool is based on occlusion technology where the cessation of blood
flow in the finger triggers a change over time of the optical
characteristics of blood," write Ohad Cohen, from Chaim Sheba Medical
Center in Tel Hashomer, Israel, and colleagues. "Increase of glucose
concentration reduces the refractive index mismatch, which in turn
reduces the scattering coefficient. This phenomenon is utilized in a
clinically applicable apparatus to measure blood glucose levels."
During hyperinsulinemic hypoglycemic clamp studies in 5 men with type 1
diabetes, insulin was infused at a constant rate, and stepped
hypoglycemia was achieved by varying glucose infusion. The Roche
Reflectron glucometer measured arterial blood glucose in parallel with
140 noninvasive readings, with values ranging from 40 to 270 mg/dL.
Blood glucose levels obtained by the two methods showed a high degree of
correlation (r=0.91) and mean error less than 10%.
"The excellent match [with arterial blood glucose measurements] prove
the reliability of this novel non-invasive glucose measuring technology
that is currently ready for large scale evaluation," the authors write.
Orsense Ltd., in Rehovot, Israel, developed this blood glucose monitor.
ADA Annual Meeting: Abstract 485-P. June 15, 2002.
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