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Re: [IP] Blood Pressure



Renee,

Congratulations!  I've heard about (and experienced) lots of cases of kidney
improvement, especially on the protein end.  Hopefully Melissa's will continue to
improve.

email @ redacted wrote:

> Rachel:
>     My 15 yr old daughter has been on ACE inhibitors for one year now. Her
> level of protein kept increasing steadily in the repeat 24 hr urine tests
> until it reached an all-time horrendous high of 2.6 grams- which is almost
> indicative of major kidney damage.  Fortunately, she was totally asymptomatic
> & the surgical kidney biopsy she had done revealed no other debilitating
> kidney diseases. It DID however corroborate recent research that it doesn't
> take 15-20 years for kidney damage to occur in those diabetics who are
> PREDISPOSED to have this occur.  In fact, the studies found evidence of slight
> changes in the "basement membrane" of the filtration system as early as 2
> years post-diagnosis, twice as frequently in girls for some unknown
> reason???...
>      Anyway, her first ACE inhibitor was Zestril which seemed to upset her
> stomach.  Then she was put on Vasotec, taking 2.5 mgs in the a.m. Her bp was
> 90/60 prior to the meds & has remained in that range - although at her most
> recent visit, it was 78/58, which her endo said was attributable to her not
> drinking enough in this heat.  The dosage was gradually increased upward over
> a period of months, so that she now takes 5mg in the a.m. & 5 mg before
> bed.....
>      But the best news of all came in late May when we re-did the 24 hr urine
> ( for about the 10th time) & got the news that the level of protein had
> decreased 80% to .28 grams.... Hard to say who was more excited- her ped.
> nephrologist or us!
> Her nephrologist said that her colleagues believe that the the success they're
> seeing with ACE inhibitors in diabetics evidencing kidney changes could change
> the course of kidney problems in years to come.  In the past, by the time they
> saw a pt. they were usually symptomatic & had lost a large percentage of their
> kidney function.
>     For those who'd already heard this saga, sorry to be redundant, but there
> are so many "newcomers" to this list, that I figured it was worth repeating.
> Melissa's doctor feels a 24 hr urine is a very small "price" to pay to be
> proactive in warding off potential deterioration.
>
> Regards, Renee (Melissa's mom)
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