RE: [IP] Type 2 Polyglandular Autoimmune Syndrome
Well, autoimmune thyroid disease is quite common, especially among women, where
it's around 4%.
APS type 2 is rare enough (about 1 in 50,000) that there is a significant
chance that you have type
I DM and Hashimoto's thyroiditis independently.
If you have another condition that is less common, such as autoimmune adrenal
(Addison's Disease), that would be much less likely to occur by coincidence.
Personally, I'm either APS-2 or a bunch of coincidences. I don't seem to have
to anything. I still produce a fair amount insulin (low-normal fasting
C-Peptide), but more insulin
sensitive than most T1's. Two out of three of my siblings are T2 -- so I was
initially assumed to be
T2, despite being life-long underweight. I'm adrenally insufficient, but that
can be explained away
as being due to steroid use for asthma. I'm hypothyroid. I have hypocalcemia --
hypoparathyroid, but could also be due to steroids. I may have Sjogren's, per a
The kicker is that my daughter has vitiligo, which is also associated with
APS-2. And I just learned
from the eMedicine article something I didn't know -- apparently there's an
Parkinson's Disease, which is what my father died of.
Out of all these endocrine issues, the one I'd most like to get rid of is the
Diabetes. (And of
course, the one I most want to avoid for my daughter). The one that has caused
me the most illness
and hospitalization is the adrenal insufficiency. But the diabetes takes so
much more effort and
attention, and the neuropathy has had such an impact, there's no question --
diabetes is the main
But I think everyone with DM T1 -- especially parents -- should be aware of the
symptoms of adrenal
insufficiency, hypothyroid, and hyperthyroid. People sometimes die of adrenal
medical personnel just don't think of it as a possibility -- until autopsy.
And if you spot potential symptoms, you should read up in detail on diagnosis
and treatment, since
doctors often don't get that right, either. My diagnosis would be a lot less
vague if the full
proper testing had been done initially.
From: email @ redacted
[mailto:email @ redacted] On Behalf Of
Sent: Wednesday, January 26, 2005 19:08
If you have this syndrome, your child's risk of
getting the syndrome including type 1 diabetes is 1 in 2.".
This got me a bit worried because I also have hypothyroidism. However,
another woman in the group who also has type I and hypothyroidism asked
her doctor about this today and he said that having type I and
hypothyroidism alone does not mean that you have type 2 polyglandular
autoimmune syndrome. Is this true? Is is really true that 1 in 7 type
I's have type 2 polyglandular autoimmune syndrome???
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