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Re: [IP] Lack of pump - glucose sensor link

If a pump were developed that delivered the insulin into the peritoneal
cavity or directly into the blood stream as opposed to delivering it in
subcutaneous tissue, the insulin should act as quickly as endogenously
produced insulin.  The CGMS would frequently check the blood glucose levels
and communicate to the pump when more insulin was needed.  Because of the
delivery of the insulin, there shouldn't be leftover insulin to consider.
So in theory, a closed loop system would provide very tight control without
lows and without requiring that the patient adhere to a schedule.  It should
be an "artificial pancreas."


----- Original Message -----
From: "Timothy O. Murphy" <email @ redacted>
To: <email @ redacted>; <email @ redacted>
Sent: Friday, January 31, 2003 12:59 PM
Subject: Re: [IP] Lack of pump - glucose sensor link
> This is my conclusion. Please tell me if I'm wrong.
> When I wore Medtronic's Continuous Glucose Monitoring System (CGMS) I saw
> there was a great lag(1-2Hrs.) between when I pumped and when the insulin
> took effect. When I pumped just before I ate my blood sugar would
> balloon(300-400) in about an hour and get real low after 2-3 Hrs.. The way
> we decided to address this was to try to take insulin .5 - 1 hr before
> eating and use the dual bolus option. This seems to work much better.
> There is no feedback loop that can predict when I'm going to eat and how
> many carbs and fats I'm going to eat. Work on closing the loop between the
> pump and glucose level measurements is a folly. I know there is a European
> consortium working on this and probably many American companies are
> on this too. It's money that should be spent elsewhere, like finding a
> with transplants or even an artificial pancreas.
> Is there a flaw in my thinking?
> Tim Murphy
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