[Previous Months][Date Index][Thread Index][Join - Register][Login]
[Message Prev][Message Next][Thread Prev][Thread Next]

[IP] Early-Onset Type 1 Diabetes Has Different Cause Than Later Childhood Onset



http://www.docguide.com/news/content.nsf/news/26A0B4B23BEC4CE8852569E00050F646?OpenDocument&id=E506012D14C17358852569E5006EE0DA&count=10&highlight=0,diabetes
DGReview

 
Early-Onset Type 1 Diabetes Has Different Cause Than Later Childhood Onset
A DGReview of :"Diabetic autoimmunity in infants and pre-schoolers with type 1 
diabetes" 
</gpc.nsf/doc?CreateDocument&n=95&id=E506012D14C17358852569E5006EE0DA&cond=Dia
betes&t=03-12-43;PM&l=News&u=/news/content.nsf/PaperFrameSet?OpenForm&id=E5060
12D14C17358852569E5006EE0DA&newsid=26A0B4B23BEC4CE8852569E00050F646&u=http://w
ww.blackwell-synergy.com/Journals/processfree2.asp?contentid=pdi.2000.2&filety
pe=abstracts&article=85566&year=&journal=&ref=/news/content.nsf/news/26A0B4B23
BEC4CE8852569E00050F646?OpenDocument&id=E506012D14C17358852569E5006EE0DA&count
=10&highlight=0,diabetes>
Pediatric Diabetes

01/29/2001
By Mark Greener

While the increase in the incidence of type 1 diabetes is most pronounced 
among children under five years of age, the demographics and autoimmune 
markers in this age group are poorly characterised. However, researchers from 
Loma Linda University Children's Hospital, CA, USA, recently identified 
several factors in patients who develop the disease as babies or toddlers that 
might suggest a different mechanism to that responsible in older children.

The authors compared 47 children who were diagnosed as suffering from type 1 
diabetes before five years of age with a representative cohort of 49 children 
diagnosed after the age of five years.

Compared to those diagnosed after the age of five years, children with 
early-onset diabetes had higher incidence of symptoms of viral illnesses and 
diabetic ketoacidosis at diagnosis.

On the other hand, haemoglobin A1C (HbA1c) levels at diagnosis were higher 
among the later-onset group. The authors commented the lower HbA1c values in 
the younger age group may indicate a shorter pre-clinical phase. Indeed, the 
authors reported that 14.8 percent of children diagnosed before five years of 
age experience a honeymoon period compared to 42.1 percent of those diagnosed 
when aged over five years.

Moreover, researchers found that the titres of antibodies against Islet-cells 
and glutamic acid decarboxylase differed between the groups. For example, 
Islet-cell antibody titers were positive in 35.29 and 70.83 percent of the 
early and late onset groups respectively. The proportions positive for 
antibodies against glutamic acid decarboxylase were 41.38 and 71.74 percent 
respectively. Titers of insulin autoantibodies after insulin treatment began 
did not differ significantly between the groups.

The authors suggested that the antibody results suggest a relative lack of 
immune markers in infants and toddlers with new-onset diabetes. This 
observation, as well as the shorter pre-clinical phase, might suggest 
age-related differences in the autoimmunity that promotes type 1 diabetes. 
Alternatively, the authors suggest that younger children might develop 
diabetes from non-autoimmune mechanisms.


Pediatric Diabetes 2000;1:131-134. "Diabetic autoimmunity in infants and 
pre-schoolers with type 1 diabetes" 
</gpc.nsf/doc?CreateDocument&n=95&id=E506012D14C17358852569E5006EE0DA&cond=Dia
betes&t=03-12-43;PM&l=News&u=/news/content.nsf/PaperFrameSet?OpenForm&id=E5060
12D14C17358852569E5006EE0DA&newsid=26A0B4B23BEC4CE8852569E00050F646&u=http://w
ww.blackwell-synergy.com/Journals/processfree2.asp?contentid=pdi.2000.2&filety
pe=abstracts&article=85566&year=&journal=&ref=/news/content.nsf/news/26A0B4B23
BEC4CE8852569E00050F646?OpenDocument&id=E506012D14C17358852569E5006EE0DA&count
=10&highlight=0,diabetes>
----------------------------------------------------------
for HELP or to subscribe/unsubscribe, contact: HELP@insulin-pumpers.org
send a DONATION http://www.Insulin-Pumpers.org/donate.shtml